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Titolo:
Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results
Autore:
Koenig, T; Lehmann, D; Saito, N; Kuginuki, T; Kinoshita, T; Koukkou, M;
Indirizzi:
Univ Bern, Hosp Clin Psychiat, CH-3000 Bern 60, Switzerland Univ Bern Bern Switzerland 60 lin Psychiat, CH-3000 Bern 60, Switzerland Univ Zurich, Hosp Psychiat, KEY Inst Brain Mind Res, CH-8029 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8029 Res, CH-8029 Zurich, Switzerland Kansai Med Univ, Dept Neuropsychiat, Moriguchi, Osaka 570, Japan Kansai Med Univ Moriguchi Osaka Japan 570 at, Moriguchi, Osaka 570, Japan
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 50, anno: 2001,
pagine: 55 - 60
SICI:
0920-9964(20010530)50:1-2<55:DFCOET>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN; COMPLEXITY; RHYTHM; MEMORY; POWER;
Keywords:
complexity; EEG; resting; schizophrenia; theta rhythm; working memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Koenig, T Univ Bern, Hosp Clin Psychiat, Bolligenstr 111, CH-3000 Bern 60,Switzerland Univ Bern Bolligenstr 111 Bern Switzerland 60 n 60, Switzerland
Citazione:
T. Koenig et al., "Decreased functional connectivity of EEG theta-frequency activity in first-episode, neuroleptic-naive patients with schizophrenia: preliminary results", SCHIZOPHR R, 50(1-2), 2001, pp. 55-60

Abstract

We explored and refined the hypothesis that during a first episode of acute schizophrenia a disorganization of brain functioning is present. A novel EEG measure was introduced, Global Field Synchronization (GFS), that estimates functional connectivity of brain processes in different EEG frequency bands. The measure was applied to EEG's from 11 never-treated, first-episode, young patients with an acute, positive, schizophrenic symptomatology and from 19 controls, residing in Bern, Switzerland. In comparison to age- and sex- matched controls, patients had significantly decreased GFS in the theta EEG frequency band, indicating a loosened functional connectivity of processes in this frequency. The result was confirmed in an independent, comparable patient group from Osaka, Japan (9 patients and 9 controls), thus making a total of 20 analyzed patients. Previous EEG research in healthy, awakesubjects indicated a positive correlation of theta activity with memory functions. Thus, our result suggests a loss of mutual interdependence of memory functions in patients with acute schizophrenia, which agrees well with previous reports of working memory dysfunction in schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 01:59:54