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Titolo:
Quantitative EEG in schizophrenia and in response to acute and chronic clozapine treatment
Autore:
Knott, V; Labelle, A; Jones, B; Mahoney, C;
Indirizzi:
Univ Ottawa, Dept Psychiat & Psychol, Ottawa, ON K1Z 7K4, Canada Univ Ottawa Ottawa ON Canada K1Z 7K4 Psychol, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp Ottawa ON Canada K1Z 7K4 st, Ottawa, ON K1Z 7K4, Canada Eli Lilly Canada Inc, Toronto, ON, Canada Eli Lilly Canada Inc Toronto ONCanada y Canada Inc, Toronto, ON, Canada
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 50, anno: 2001,
pagine: 41 - 53
SICI:
0920-9964(20010530)50:1-2<41:QEISAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM RESPONSE; COMPUTERIZED EEG; HALOPERIDOL TREATMENT; PSYCHIATRIC-SYMPTOMS; SPECTRAL ANALYSIS; PLASMA-LEVELS; PHARMACO-EEG; PERFORMANCE; CHLORPROMAZINE; TOPOGRAPHY;
Keywords:
clozapine; electroencephalography; global psychopathology; positive and negative symptoms; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Knott, V Univ Ottawa, Dept Psychiat & Psychol, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada Univ Ottawa 1145 Carling Ave Ottawa ON Canada K1Z 7K4 7K4, Canada
Citazione:
V. Knott et al., "Quantitative EEG in schizophrenia and in response to acute and chronic clozapine treatment", SCHIZOPHR R, 50(1-2), 2001, pp. 41-53

Abstract

Topographic quantitative electroencephalographic (EEG) power and frequencyindices were collected in 17 treatment refractory, DSM-III diagnosed schizophrenic patients, before and after acute (single dose) and chronic (six weeks) clozapine treatment, as well as in 17 healthy volunteers. Prior to treatment, patients exhibited greater overall absolute theta power, slower mean alpha frequency and elevated absolute delta and total power in anterior regions. Acute dosing increased total spectrum power globally, slow wave power posteriorally, mean alpha frequency and beta power anteriorally and decreased alpha power posteriorally. Six weeks of clozapine treatment significantly reduced clinical ratings of positive and negative symptoms as well as symptoms of global psychopathology. Chronic treatment resulted in EEG slowing as shown by decreases in relative alpha power, mean beta/total spectrum frequency and by widespread increases in absolute total and delta/theta power. The preliminary findings suggest that brain electric profiling may be apromising tool for assessing and understanding the central impact of pharmacotherapeutic interventions in schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:15:37