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Titolo:
Differential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder
Autore:
Kircher, TTJ; Bulimore, ET; Brammer, MJ; Williams, SCR; Broome, MR; Murray, RM; McGuire, PK;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Inst Psychiat, Neuroimaging Unit, London SE5 8AF, England Inst Psychiat London England SE5 8AF aging Unit, London SE5 8AF, England GKT Sch Med, London SE5 8AF, England GKT Sch Med London England SE5 8AFGKT Sch Med, London SE5 8AF, England Inst Psychiat, Dept Biostat & Comp, London SE5 8AF, England Inst PsychiatLondon England SE5 8AF tat & Comp, London SE5 8AF, England
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 50, anno: 2001,
pagine: 27 - 40
SICI:
0920-9964(20010530)50:1-2<27:DAOTCD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCORTICAL SENSORY APHASIA; ATTENUATED FRONTAL ACTIVATION; FIRST-EPISODE SCHIZOPHRENIA; GENERIC BRAIN ACTIVATION; VERBAL FLUENCY TASK; RIGHT-HEMISPHERE; PLANUM TEMPORALE; DAMAGED PATIENTS; SEMANTIC SYSTEM; LANGUAGE;
Keywords:
functional magnetic resonance imaging; language; neuroimaging studies; schizophrenia; sentence completion; temporal cortex activation; thought disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Kircher, TTJ Inst Psychiat, Dept Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF England
Citazione:
T.T.J. Kircher et al., "Differential activation of temporal cortex during sentence completion in schizophrenic patients with and without formal thought disorder", SCHIZOPHR R, 50(1-2), 2001, pp. 27-40

Abstract

The neural correlates of processing linguistic context in schizophrenic patients with formal thought disorder (FTD) were examined. Six right-handed male patients with prominent 'positive' FTD were compared with six schizophrenic patients without FTD and seven volunteers, matched for cognitive and demographic variables. Functional magnetic resonance imaging (IMRI) was usedto measure cerebral activation while subjects read and completed sentence stems out loud. During a GENERATION condition, subjects were required to generate a word which completed the sentence stem appropriately. During a DECISION condition, subjects selected and articulated one of two presented terminal words. A READING condition served as baseline. The three conditions were compared with each other. Regions activated were identified in each group, and between-group differences were detected using an ANCOVA. When GENERATION was compared with READING, FTD patients showed less activation in theright superior temporal gyrus than patients without FTD or controls, but greater activation in the left inferior frontal, inferior temporal and fusiform gyri. FTD patients also showed an attenuated right temporal response when GENERATION was compared with DECISION. This differential engagement of the right temporal cortex was independent of differences in the speed or accuracy of responses, whereas the left fronto-temporal differences in activation were not evident after covarying for task errors. The attenuated engagement of right temporal cortex, which is implicated in language comprehension at the discourse level, is consistent with neuropsychological evidence linking thought disorder with deficits in processing linguistic context. (C) 2001 Elsevier Science B.V, All rights reserved.

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Documento generato il 17/01/20 alle ore 20:12:43