Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia
Autore:
Paillere-Martinot, ML; Caclin, A; Artiges, E; Poline, JB; Joliot, M; Mallet, L; Recasens, C; Attar-Levy, D; Martinot, JL;
Indirizzi:
CEA, Serv Hosp Frederic Joliot, DSV, F-91406 Orsay, France CEA Orsay France F-91406 osp Frederic Joliot, DSV, F-91406 Orsay, France Ecole Normale Super, F-75005 Paris, France Ecole Normale Super Paris France F-75005 le Super, F-75005 Paris, France Hop La Pitie Salpetriere, Serv Psychiat 1, AP HP, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 HP, F-75013 Paris, France Ctr Hosp Orsay, Secteur 91 G 16, F-91401 Orsay, France Ctr Hosp Orsay Orsay France F-91401 cteur 91 G 16, F-91401 Orsay, France Hop Albert Chenevier, AP HP, F-94000 Creteil, France Hop Albert ChenevierCreteil France F-94000 HP, F-94000 Creteil, France Hop St Anne, SHU, F-75014 Paris, France Hop St Anne Paris France F-75014Hop St Anne, SHU, F-75014 Paris, France CNRS FRE 2233, F-14074 Caen, France CNRS FRE 2233 Caen France F-14074CNRS FRE 2233, F-14074 Caen, France CEA, F-14074 Caen, France CEA Caen France F-14074CEA, F-14074 Caen, France
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 50, anno: 2001,
pagine: 19 - 26
SICI:
0920-9964(20010530)50:1-2<19:CGAWMR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN VOLUMES; ABNORMALITIES; POSTMORTEM; DISORDER; ILLNESS; IMAGES; AGE; MEN;
Keywords:
early onset; gray matter; magnetic resonance imaging; negative symptoms; schizophrenia; white matter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Paillere-Martinot, ML CEA, Serv Hosp Frederic Joliot, DSV, 4 Pl Gen Leclerc, F-91406 Orsay, France CEA 4 Pl Gen Leclerc Orsay France F-91406 y, France
Citazione:
M.L. Paillere-Martinot et al., "Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia", SCHIZOPHR R, 50(1-2), 2001, pp. 19-26

Abstract

Few magnetic resonance imaging studies of schizophrenia have investigated brain tissue volumes and their relation to clinical symptoms in patients with an early age at illness onset. The twofold purpose of the study was to investigate both gray and white matter volumes in schizophrenic men with an early age at illness onset, and to determine whether clinical features correlated with tissue volume changes, using an automated voxel-by-voxel image analysis procedure. Twenty male patients with DSM-IV diagnoses of schizophrenia, and an early age at onset (m +/- SD = 19 +/- 2) were compared with 20age-matched health men. Magnetic resonance (1.5-T) scans were obtained with an Inversion-Recovery prepared fast gradient echo sequence enhancing grayand white matter contrast. Statistical Parametric Mapping was used for image segmentation and comparison. Patients had significant gray matter reductions in medial frontal gyri, left insula, left parahippocampus. and left fusiform gyrus; bilateral white matter reductions in frontal lobes, and increased total cerebrospinal fluid volume were also observed. Negative symptom scores were negatively related to white matter volumes in cingulate regions, and in the right internal capsule. These findings emphasize a pattern of left-hemisphere gray matter abnormalities, and suggest that fronto-paralimbic connectivity may be altered in men with early onset schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:42:04