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Titolo:
Clinical efficacy of pramipexole in the treatment of conditions other thanParkinson's disease
Autore:
Becker, PM; Corrigan, MH; Kasper, S; Lin, SC; Montplaisir, J; Szegedi, A; Willner, P;
Indirizzi:
Pharmacia Inc, Peapack, NJ 07977 USA Pharmacia Inc Peapack NJ USA 07977Pharmacia Inc, Peapack, NJ 07977 USA Univ Vienna, Dept Gen Psychiat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Gen Psychiat, A-1090 Vienna, Austria Mayo Clin Jacksonville, Sleep Disorders Ctr, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA Hop Sacre Coeur, Ctr Etud Sommeil, Montreal, PQ H4J 1C5, Canada Hop Sacre Coeur Montreal PQ Canada H4J 1C5 , Montreal, PQ H4J 1C5, Canada Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany Univ Wales, Ctr Subst Abuse Res, Swansea SA2 8PP, W Glam, Wales Univ Wales Swansea W Glam Wales SA2 8PP s, Swansea SA2 8PP, W Glam, Wales
Titolo Testata:
REVIEWS IN CONTEMPORARY PHARMACOTHERAPY
fascicolo: 1-2, volume: 12, anno: 2001,
pagine: 87 - 104
SICI:
0954-8602(2001)12:1-2<87:CEOPIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTLESS LEGS SYNDROME; PROGRESSIVE SUPRANUCLEAR PALSY; DOPAMINE-RECEPTOR AGONIST; STRESS-INDUCED ANHEDONIA; SEROTONIN REUPTAKE INHIBITOR; RANDOMIZED CROSSOVER TRIAL; PERIODIC LIMB MOVEMENTS; MYOCLONUS SYNDROME NMS; DOUBLE-BLIND; ENDOGENOUS-DEPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
163
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, PM Box 15, Carnforth LA6 1HW, England Box 15 Carnforth England LA6 1HW , Carnforth LA6 1HW, England
Citazione:
P.M. Becker et al., "Clinical efficacy of pramipexole in the treatment of conditions other thanParkinson's disease", REV CONT PH, 12(1-2), 2001, pp. 87-104

Abstract

The non-ergot dopamine receptor agonist, pramipexole, which shows affinityfor the D-2 and D-3 subtypes of the D2 dopamine receptor subfamily, with preference for the D-3 receptor, is currently licensed for the treatment of advanced-stage Parkinson's disease in the European Union, and for both early and advanced-stage Parkinson's disease in the USA and Canada. There are, however, intriguing reports that this agent may also have other beneficial clinical effects on symptoms associated with, or occurring independently of, Parkinson's disease. It has been shown that depression, which is a frequent accompaniment of Parkinson's disease, may not necessarily be simply an emotional reaction to the parkinsonian symptoms but could be aetiopathotogically linked to the same underlying dopaminergic mechanisms. There is evidence that pramipexole can alleviate mild-to-moderate depression, whether or not this occurs in association with Parkinson's disease. Such findings may throw interesting new light on the involvement of dopaminergic processes in depressive illness. Pramipexole may also have an antianxiety potential, though currently it is not clear whether this is secondary to, or independent of, its antidepressive actions. Although some studies have been conducted on possible antischizophrenic effects of pramipexole, these have generally been small and have either given negative results or have suggested that thetreatment may alleviate negative schizophrenic symptoms, with effects on positive symptoms being less evident. Pramipexole is a potent treatment for restless legs syndrome (RLS), a dose of 0.375-0.75 mg/day producing complete relief of symptoms in the majority of cases. Other conditions in which pramipexole might be expected to produce some clinical improvements include attention-deficit-hyperactivity disorder, sexual impotence in males, cocaineaddiction, and supranuclear palsy, though no direct evidence currently exists to support any of these putative applications. Exploration of the profile of clinical effectiveness of pramipexole may be expected to throw interesting new light on the interrelationships between a range of neurological and neuropsychiatric conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:34:36