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Titolo:
Serum levels of the brain-derived proteins S-100 and NSE predict long-termoutcome after cardiac arrest
Autore:
Rosen, H; Sunnerhagen, KS; Herlitz, J; Blomstrand, C; Rosengren, L;
Indirizzi:
Gothenburg Univ, Sahlgrens Univ Hosp, Dept Neurol, Inst Clin Neurosci, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 ci, S-41345 Gothenburg, Sweden Gothenburg Univ, Sahlgrens Univ Hosp, Dept Rehabil Med, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 ed, S-41345 Gothenburg, Sweden Gothenburg Univ, Sahlgrens Univ Hosp, Div Cardiol, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 ol, S-41345 Gothenburg, Sweden
Titolo Testata:
RESUSCITATION
fascicolo: 2, volume: 49, anno: 2001,
pagine: 183 - 191
SICI:
0300-9572(200105)49:2<183:SLOTBP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; CEREBROSPINAL-FLUID; INFARCTION; GUIDELINES; INDICATORS; PROGNOSIS; ISCHEMIA; STROKE; SCALE; BLOOD;
Keywords:
cardiac arrest; neuron specific enolase; S-100;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Rosen, H Gothenburg Univ, Sahlgrens Univ Hosp, Dept Neurol, Inst Clin Neurosci, S-41345 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41345 45 Gothenburg, Sweden
Citazione:
H. Rosen et al., "Serum levels of the brain-derived proteins S-100 and NSE predict long-termoutcome after cardiac arrest", RESUSCITAT, 49(2), 2001, pp. 183-191

Abstract

Background and purpose: patients with cardiac arrest have a high mortalityand the long-term outcome is doubtful. The prognosis is mainly dependent on clinical parameters. S-100 and neurone specific enolase (NSE) are established biochemical markers of central nervous system (CNS) injury. The purpose of this study was to validate the use of serum determinations of S-100 and NSE with neurological investigations in regard to brain damage and long-term outcome after cardiac arrest. Methods: neurological examinations were performed on 66 patients after cardiac arrest. Serum levels of S-100 and NSEwere determined during the first 3 days of post arrest, using commercial luminescent immunoassays (LIAs). The main outcome variable was the Glasgow Outcome Scale (GOS), while secondary variables were the activity of daily living (ADL) index and mini mental state examination (MMSE). Outcome was determined at 1 year. Results: the serum levels of S-100 and NSE were increasedduring the first 3 days after the arrest and were related to coma depth, time of anoxia and abnormal brain stem reflexes. High levels predicted a poor outcome, according to the GOS (death, vegetative state and severe disability). The prognostic Value of the brain damage markers was comparable with that of traditional clinical parameters. None of the secondary outcome variables (ADL and MMSE) was strongly associated with S-100 or NSE. Discussion:the serum levels of S-100 and NSE increased after cardiac arrest due to the anoxic brain damage. The determination of S-100 and NSE can be used as anadjunct to predict long-term outcome after cardiac arrest. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:38:08