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Titolo:
Alveolar epithelial type II cell: defender of the alveolus revisited
Autore:
Fehrenbach, H;
Indirizzi:
TU Dresden, Univ Clin Carl Gustav Carus, Inst Pathol, D-01307 Dresden, Germany TU Dresden Dresden Germany D-01307 Inst Pathol, D-01307 Dresden, Germany
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 1, volume: 2, anno: 2001,
pagine: 33 - 52
SICI:
1465-993X(2001)2:1<33:AETICD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACTANT PROTEIN-A; IDIOPATHIC PULMONARY FIBROSIS; KERATINOCYTE GROWTH-FACTOR; COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; LUNG LAMELLAR BODIES; FACTOR-INDUCED HYPERPLASIA; HUMAN FETAL LUNG; RAT LUNG; GENE-EXPRESSION;
Keywords:
alveolar epithelium; apoptosis; cell-cell interactions; repair; surfactant;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
292
Recensione:
Indirizzi per estratti:
Indirizzo: Fehrenbach, H TU Dresden, Univ Clin Carl Gustav Carus, Inst Pathol, Fetscherstr 74, D-01307 Dresden, Germany TU Dresden Fetscherstr 74 Dresden Germany D-01307 , Germany
Citazione:
H. Fehrenbach, "Alveolar epithelial type II cell: defender of the alveolus revisited", RESPIR RES, 2(1), 2001, pp. 33-52

Abstract

In 1977, Mason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactantthat regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the hypophase. AE2 cells play various roles in alveolar fluid balance, coagulation/fibrinolysis, and host defence. AE2 cells proliferate, differentiate into AE1 cells, and remove apoptotic AE2 cells by phagocytosis, thus contributing to epithelial repair. AE2 cells may act as immunoregulatory cells. AE2 cells interact with resident and mobile cells, either directly by membrane contact or indirectly via cytokines/growth factors andtheir receptors, thus representing an integrative unit within the alveolus. Although most data support the concept, the controversy about the character of hyperplastic AE2 cells, reported to synthesise profibrotic factors, proscribes drawing a definite conclusion today.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:37:33