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Titolo:
Antenatal infection/inflammation and postnatal lung maturation and injury
Autore:
Jobe, AH; Ikegami, M;
Indirizzi:
Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 Med Ctr, Cincinnati, OH 45229 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 1, volume: 2, anno: 2001,
pagine: 27 - 32
SICI:
1465-993X(2001)2:1<27:AIAPLM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL INFLAMMATORY RESPONSE; NECROSIS-FACTOR-ALPHA; RESPIRATORY-DISTRESS SYNDROME; BIRTH-WEIGHT INFANTS; BRONCHOPULMONARY DYSPLASIA; CYTOKINES INTERLEUKIN-6; UREAPLASMA-UREALYTICUM; PREMATURE BIRTH; CEREBRAL-PALSY; PRETERM LAMBS;
Keywords:
alveolarization; amnionitis; bronchopulmonary dysplasia; cytokines; respiratory distress syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Jobe, AH 3333 Burnet Ave, Cincinnati, OH 45229 USA 3333 Burnet Ave Cincinnati OH USA 45229 Cincinnati, OH 45229 USA
Citazione:
A.H. Jobe e M. Ikegami, "Antenatal infection/inflammation and postnatal lung maturation and injury", RESPIR RES, 2(1), 2001, pp. 27-32

Abstract

Chorioamnionitis is frequently associated with preterm deliveries before 30 weeks gestation. Chorioamnionitis correlates both with an increased risk of bronchopulmonary dysplasia and with a decreased risk of respiratory distress syndrome. Both interleukin-1 alpha and endotoxin can induce inflammation in the fetal lungs and lung maturation after preterm birth when given byintra-amniotic injection. Inflammation can also result in an arrest of alveolarization, and this lung developmental abnormality is prominent in the lungs of preterm infants that die of bronchopulmonary dysplasia. The mechanisms by which infection/inflammation can have both beneficial and injurious effects on the preterm lung remain to be characterized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:58:34