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Titolo:
The genetics of chronic obstructive pulmonary disease
Autore:
Lomas, DA; Silverman, EK;
Indirizzi:
Univ Cambridge, Dept Med, Cambridge Inst Med Res, Wellcome Trust Ctr Mol Mechanisms Dis, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY Dis, Cambridge CB2 2XY, England Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 1, volume: 2, anno: 2001,
pagine: 20 - 26
SICI:
1465-993X(2001)2:1<20:TGOCOP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD RESPIRATORY-INFECTION; MICROSOMAL EPOXIDE HYDROLASE; AIR-FLOW OBSTRUCTION; ACUTE-PHASE RESPONSE; LUNG-DISEASE; CHRONIC-BRONCHITIS; ALPHA-1-ANTITRYPSIN GENE; NATURAL-HISTORY; AIRWAYS OBSTRUCTION; PHENOTYPE SUBJECTS;
Keywords:
association studies; chronic obstructive pulmonary disease; emphysema; genetics; lungs;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lomas, DA Univ Cambridge, Dept Med, Cambridge Inst Med Res, Wellcome TrustCtr Mol Mechanisms Dis, Hills Rd, Cambridge CB2 2XY, England Univ Cambridge Hills Rd Cambridge England CB2 2XY 2XY, England
Citazione:
D.A. Lomas e E.K. Silverman, "The genetics of chronic obstructive pulmonary disease", RESPIR RES, 2(1), 2001, pp. 20-26

Abstract

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:39:38