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Titolo:
Is there a role for glucocorticoid receptor beta in asthma?
Autore:
Gagliardo, R; Vignola, AM; Mathieu, M;
Indirizzi:
CHU Montpellier, INSERM, U454, Montpellier, France CHU Montpellier Montpellier France r, INSERM, U454, Montpellier, France CNR, Ist Fisiopatol Resp, Palermo, Italy CNR Palermo ItalyCNR, Ist Fisiopatol Resp, Palermo, Italy
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 1, volume: 2, anno: 2001,
pagine: 1 - 4
SICI:
1465-993X(2001)2:1<1:ITARFG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; DOWN-REGULATION; IN-VIVO; EXPRESSION; ISOFORM; ALPHA; MECHANISMS; GENE; LYMPHOCYTES; RESISTANCE;
Keywords:
asthma; glucocorticoid receptor;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Mathieu, M Hop A de Villeneuve, INSERM, U454, F-34295 Montpellier 5, France Hop A de Villeneuve Montpellier France 5 ontpellier 5, France
Citazione:
R. Gagliardo et al., "Is there a role for glucocorticoid receptor beta in asthma?", RESPIR RES, 2(1), 2001, pp. 1-4

Abstract

Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in thetreatment of asthma. They act through binding to glucocorticoid receptor alpha (GR alpha), which represses numerous genes encoding pro-inflammatory mediators. A hormone binding deficient GR isoform named GR beta has been isolated in humans. When overexpressed by transfection, GR beta may function as a dominant negative modulator of GR alpha. However, to act as such, GR beta has to be more abundant than GR alpha, and conflicting data have been obtained concerning the relative levels of the two isoforms in cell lines andfreshly isolated cells. Moreover, the dominant negative effect was not confirmed by independent laboratories. In GC-resistant asthmatics, GR beta wasexpressed by an increased number of peripheral blood mononuclear cells (PBMCs), airway T cells, and cells found in skin biopsies of tuberculin responses. However, the relative amounts of GR alpha and GR beta in these cells were not determined. In GC-dependent asthmatics, PBMCs expressed GR alpha predominantly. No cells containing higher levels of GR beta than GR alpha have yet been reported in asthmatics. Even if the existence of such cells is demonstrated, the role of GR beta in asthma will remain a matter of controversy because functional studies have given discrepant data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:07:11