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Titolo:
Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma
Autore:
Palmer, LJ; Cookson, WOCM;
Indirizzi:
Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Case Western Reserve Univ, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Wellcome Trust Ctr Human Genet, Oxford, England Wellcome Trust Ctr Human Genet Oxford England an Genet, Oxford, England
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 2, volume: 2, anno: 2001,
pagine: 102 - 112
SICI:
1465-993X(2001)2:2<102:USNPAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM IGE LEVELS; GENOME-WIDE SEARCH; FC-EPSILON-RI; IMMUNOGLOBULIN-E RECEPTOR; QUANTITATIVE TRAIT LOCI; LINKAGE DISEQUILIBRIUM; BETA(2)-ADRENERGIC RECEPTOR; COMPLEX TRAITS; BETA-SUBUNIT; CYSTIC-FIBROSIS;
Keywords:
association studies; asthma; genetics; review; SNP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
162
Recensione:
Indirizzi per estratti:
Indirizzo: Palmer, LJ Brigham & Womens Hosp, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Brigham & Womens Hosp 181 Longwood Ave Boston MA USA 02115 USA
Citazione:
L.J. Palmer e W.O.C.M. Cookson, "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma", RESPIR RES, 2(2), 2001, pp. 102-112

Abstract

Asthma is the most common chronic childhood disease in the developed nations, and is a complex disease that has high social and economic costs. Studies of the genetic etiology of asthma offer a way of improving our understanding of its pathogenesis, with the goal of improving preventive strategies,diagnostic tools, and therapies. Considerable effort and expense have beenexpended in attempts to detect specific polymorphisms in genetic loci contributing to asthma susceptibility. Concomitantly, the technology for detecting single nucleotide polymorphisms (SNPs) has undergone rapid development,extensive catalogues of SNPs across the genome have been constructed, and SNPs have been increasingly used as a method of investigating the genetic etiology of complex human diseases. This paper reviews both current and potential future contributions of SNPs to our understanding of asthma pathophysiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:53:23