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Titolo:
Role of epidermal growth factor receptor activation in regulating mucin synthesis
Autore:
Nadel, JA;
Indirizzi:
Univ Calif San Francisco, Dept Med, Inst Cardiovasc Res, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Dept Physiol, Inst Cardiovasc Res, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 2, volume: 2, anno: 2001,
pagine: 85 - 89
SICI:
1465-993X(2001)2:2<85:ROEGFR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GOBLET CELLS; EPITHELIAL REPAIR; NASAL POLYPS; RAT AIRWAYS; ENDOTOXIN; ASTHMA; MUCUS; EOSINOPHILS; EXPRESSION; SECRETION;
Keywords:
activated neutrophils; airway goblet cell; asthma; chronic intubation; cigarette smoke; nasal polyp; oxygen free radical; tumor necrosis factor-alpha;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Nadel, JA Univ Calif San Francisco, Dept Med, Inst Cardiovasc Res, 505 Parnassus,Room M-1325 Box 0130, San Francisco, CA 94143 USA Univ Calif San Francisco 505 Parnassus,Room M-1325 Box 0130 San Francisco CA USA 94143
Citazione:
J.A. Nadel, "Role of epidermal growth factor receptor activation in regulating mucin synthesis", RESPIR RES, 2(2), 2001, pp. 85-89

Abstract

Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this occurs via cell multiplication. The mechanisms that determine which pathway is chosen are critical but largely unknown. Although no effective therapy exists for hypersecretion at present, the EGFR cascade suggests methods for effective therapeutic intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 07:48:00