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Titolo:
Th2 cytokines and asthma - The role of interleukin-5 in allergic eosinophilic disease
Autore:
Greenfeder, S; Umland, SP; Cuss, FM; Chapman, RW; Egan, RW;
Indirizzi:
Schering Plough Corp, Res Inst, Dept Allergy, Kenilworth, NJ 07033 USA Schering Plough Corp Kenilworth NJ USA 07033 gy, Kenilworth, NJ 07033 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 2, volume: 2, anno: 2001,
pagine: 71 - 79
SICI:
1465-993X(2001)2:2<71:TCAA-T>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; RECOMBINANT HUMAN INTERLEUKIN-5; MESSENGER-RNA EXPRESSION; CELL-REPLACING FACTOR; BRONCHOALVEOLAR LAVAGE CELLS; SEGMENTAL ANTIGEN CHALLENGE; HUMAN T-CELLS; GENE-EXPRESSION; BRONCHIAL HYPERREACTIVITY; PULMONARY INFLAMMATION;
Keywords:
allergy; asthma; eosinophil; interleukin-5;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Greenfeder, S Schering Plough Corp, Res Inst, Dept Allergy, 2015 GallopingHill Rd, Kenilworth, NJ 07033 USA Schering Plough Corp 2015 Galloping HillRd Kenilworth NJ USA 07033
Citazione:
S. Greenfeder et al., "Th2 cytokines and asthma - The role of interleukin-5 in allergic eosinophilic disease", RESPIR RES, 2(2), 2001, pp. 71-79

Abstract

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:48:50