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Titolo:
Eotaxin and the attraction of eosinophils to the asthmatic lung
Autore:
Conroy, DM; Williams, TJ;
Indirizzi:
Imperial Coll Sch Med, Div Biomed Sci, Leukocyte Biol Sect, London SW7 2AZ, England Imperial Coll Sch Med London England SW7 2AZ ct, London SW7 2AZ, England
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 3, volume: 2, anno: 2001,
pagine: 150 - 156
SICI:
1465-993X(2001)2:3<150:EATAOE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CC-CHEMOKINE RECEPTOR-3; MESSENGER-RNA EXPRESSION; GUINEA-PIG MODEL; IN-VIVO; TISSUE EOSINOPHILIA; MOLECULAR-CLONING; ENDOTHELIAL-CELLS; AIRWAY HYPERRESPONSIVENESS; CHEMOATTRACTANT CYTOKINE; ALLERGIC INFLAMMATION;
Keywords:
allergy; asthma; chemokines; eosinophils; eotaxin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Conroy, DM Imperial Coll Sch Med, Div Biomed Sci, Leukocyte Biol Sect, SirAlexander Fleming Bldg, London SW7 2AZ, England Imperial Coll Sch Med Sir Alexander Fleming Bldg London England SW7 2AZ
Citazione:
D.M. Conroy e T.J. Williams, "Eotaxin and the attraction of eosinophils to the asthmatic lung", RESPIR RES, 2(3), 2001, pp. 150-156

Abstract

Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and are believed to be important in the pathogenisis of asthma. A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-helper (Th) 2 lymphocytes. Low molecular weight compounds have been developed that can block the eotaxin receptor C-C chemokine receptor (CCR)3, and prevent stimulation by eotaxin. This provides the potential for orally available drugs that can prevent eosinophil recruitment into the lung and the associated damage and dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:45:44