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Titolo:
Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors
Autore:
Peers, C; Kemp, PJ;
Indirizzi:
Univ Leeds, Acad Unit Cardiovasc Med, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 3, volume: 2, anno: 2001,
pagine: 145 - 149
SICI:
1465-993X(2001)2:3<145:AOSDBC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CAROTID-BODY; PROTEIN-KINASE-C; NADPH-OXIDASE; K+ CURRENT; NEUROEPITHELIAL BODIES; GLOMUS CELLS; HYPOXIA; CHANNELS; SENSORS; RABBIT;
Keywords:
carotid body; chemoreceptor; hypoxia; neuroepithelial body; O-2 sensing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Peers, C Univ Leeds, Acad Unit Cardiovasc Med, Worsley Bldg, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Worsley Bldg Leeds W Yorkshire England LS2 9JT England
Citazione:
C. Peers e P.J. Kemp, "Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors", RESPIR RES, 2(3), 2001, pp. 145-149

Abstract

Airway neuroepithelial bodies sense changes in inspired O-2, whereas arterial O-2 levels are monitored primarily by the carotid body. Both respond tohypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face of a potentially deleterious O-2 supply. Oneunifying theme underpinning chemotransduction in these tissues is K+ channel inhibition. However, the transduction components, from O-2 sensor to K+ channel, display considerable tissue specificity yet result in analogous end points. Here we highlight how emerging data are contributing to a more complete understanding of O-2 chemosensing at the molecular level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:35:18