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Titolo:
A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation
Autore:
Mechan, AO; OShea, E; Elliott, JM; Colado, MI; Green, AR;
Indirizzi:
De Montfort Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Leicester LE1 9BH, Leics, England De Montfort Univ Leicester Leics England LE1 9BH LE1 9BH, Leics, England Univ Nottingham, Sch Med, Sch Biomed Sci, Queens Med Ctr, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England Univ Complutense, Fac Med, Dept Farmacol, Madrid 28040, Spain Univ Complutense Madrid Spain 28040 , Dept Farmacol, Madrid 28040, Spain
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 155, anno: 2001,
pagine: 413 - 418
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-CHLOROAMPHETAMINE; METHYLENEDIOXYMETHAMPHETAMINE MDMA; SEROTONERGIC TOXICITY; AMBIENT-TEMPERATURE; HYPERTHERMIA; FENFLURAMINE; RESPONSES; NEURODEGENERATION; HYPOTHERMIA; DIZOCILPINE;
Keywords:
MDMA; ecstasy; 3,4-methylenedioxymethamphetamine; 5-HT; thermoregulation; hyperthermia; neurodegeneration; 8-OH-DPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Green, AR De Montfort Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Gateway, Leicester LE1 9BH, Leics, England De Montfort Univ Gateway LeicesterLeics England LE1 9BH England
Citazione:
A.O. Mechan et al., "A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation", PSYCHOPHAR, 155(4), 2001, pp. 413-418

Abstract

Rationale: 3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") administration to rats produces damage to cerebral 5-HT nerve endings; however, the long-term functional consequences of this damage are poorly understood. Objective: To confirm that MDMA administration produces a long-term effect on thermoregulation and investigate the mechanisms involved. Methods: Male Dark Agouti rats were injected with a neurotoxic dose of MDMA (12.5 mg/kg IF). Five to 6 weeks later, they were exposed to high ambient temp (30 degreesC) for 60 min followed by a return to normal temp (20 degreesC), with rectal temperature being measured under both conditions. Further groups of MDMA-pretreated rats were challenged with 8-OH-DPAT and their temperature response measured. Results: MDMA administration produced acute hyperthermia. Rectal temperature had normalised 24 h later and was similar to saline-injected controls over the following 15 days. MDMA administration produced a 37% loss in hypothalamic 5-HT content 18 days later. When MDMA-pretreated rats were subjected to high ambient temperature 33 days posttreatment, they displayedboth a faster rise in rectal temperature and sustained hyperthermia when returned to normal conditions. There was no difference in their hypothermic response to the 5-HT,, agonist 8-OH-DPAT, Conclusions: A neurotoxic dose ofMDMA resulted in impaired thermoregulation when rats MDMA presumably alters the neurotransmitter balance, thereby compromising thermoregulation. Heavy recreational users of MDMA may also have impaired thermoregulation and thus be at greater risk of an acute adverse response to MDMA in a hot crowdeddance environment.

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Documento generato il 23/01/20 alle ore 04:02:30