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Titolo:
The alpha(2) adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats
Autore:
McAllister, KH;
Indirizzi:
Novartis Pharma, Nervous Syst Dept, CH-4002 Basel, Switzerland Novartis Pharma Basel Switzerland CH-4002 pt, CH-4002 Basel, Switzerland
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 155, anno: 2001,
pagine: 379 - 388
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY PERFORMANCE; OPERANT DNMTP TASK; PREFRONTAL CORTEX; AGED RATS; ALPHA-2-ADRENOCEPTOR ANTAGONISTS; IDAZOXAN; CLONIDINE; MONKEYS; AGONIST; SCOPOLAMINE;
Keywords:
DNMTP; yohimbine; RX 821002 (2-methoxy-idazoxan); scopolamine; alpha adrenoceptor; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: McAllister, KH Novartis Pharma, Nervous Syst Dept, WSJ-106-241, CH-4002 Basel, Switzerland Novartis Pharma WSJ-106-241 Basel Switzerland CH-4002 land
Citazione:
K.H. McAllister, "The alpha(2) adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats", PSYCHOPHAR, 155(4), 2001, pp. 379-388

Abstract

Rationale: alpha (2) adrenoceptor mechanisms appear to play a role in the performance of delayed response working memory tasks but there are contradictory results. Objective: To investigate whether RX 821002 (2-methoxy-idazoxan) and yohimbine and would affect the performance of the delayed non-matching-to-position (DNMTP) task in rats and compare the effects to those of the cholinergic antagonist scopolamine. Methods: Male Lister Hooded rats trained to criterion in an operant DNMTP task (0-48 s delay intervals) were administered vehicle, RX 821002 (0.3, 1, 3 mg/kg s.c.), yohimbine (1, 3 mg/kg. s.c.) or scopolamine (0.05 mg/kg, s.c.). Together with choice accuracy, the motor performance of the task was measured. Results: It was found that: (1) both RX 821002 and yohimbine statistically significantly reduced choiceaccuracy dose- and delay-dependently and in a similar magnitude to that ofscopolamine while modifying the motor aspects of task performance delay-independently and (2) RX 821002 produced mainly rate-decreasing effects. Yohimbine exerted stimulatory effects at the lowest dose and rate-decreasing effects at the highest dose, a profile consistent with that already describedin operant tasks. Conclusion: The results confirm that alpha (2) antagonists delay-dependently impair choice accuracy in a delayed-response paradigm.

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Documento generato il 25/02/20 alle ore 07:51:00