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Titolo:
Behavioral and neurochemical consequences of repeated nicotine treatment in the serotonin-depleted rat
Autore:
Olausson, P; Akesson, P; Petersson, A; Engel, JA; Soderpalm, B;
Indirizzi:
Univ Gothenburg, Dept Pharmacol, S-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-40530 ol, S-40530 Gothenburg, Sweden Univ Gothenburg, Dept Clin Neurosci, S-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-40530 ci, S-40530 Gothenburg, Sweden
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 155, anno: 2001,
pagine: 348 - 361
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS NEURONS; 5-HT3 RECEPTOR ANTAGONIST; INDUCED DOPAMINE RELEASE; VENTRAL TEGMENTAL AREA; LOCOMOTOR-ACTIVITY; PREFRONTAL CORTEX; COCAINE SENSITIZATION; STRIATAL DOPAMINE; SYSTEMIC NICOTINE; DECISION-MAKING;
Keywords:
5,7-DHT; behavioral sensitization; behavioral disinhibition; dopamine; serotonin; elevated plus-maze; locomotor activity; microdialysis; nicotine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Olausson, P Yale Univ, Dept Psychiat, 34 Pk St, New Haven, CT 06508 USA Yale Univ 34 Pk St New Haven CT USA 06508 Haven, CT 06508 USA
Citazione:
P. Olausson et al., "Behavioral and neurochemical consequences of repeated nicotine treatment in the serotonin-depleted rat", PSYCHOPHAR, 155(4), 2001, pp. 348-361

Abstract

Rationale: Repeated exposure to addictive drugs causes neuroadaptive alterations that are proposed to increase the incentive motivation to consume drugs and to decrease the ability to inhibit such inappropriate motivational impulses and responses. Together, these behavioral consequences of drug intake may underlie the compulsive drug-seeking and -taking behaviors observedin drug abuse. Objective. Brain serotonin (5-HT) has been implicated in these mechanisms and this study therefore investigated the consequences of brain 5-HT depletion on the behavioral and neurochemical effects induced by repeated daily nicotine treatment (15 days) in male rats. Methods: The effects of the present pharmacological manipulations were evaluated behaviorally(locomotor activity, the elevated plus-maze) and neurochemically (microdialysis, brain biochemistry). Results: Depletion of brain 5-HT produced behavioral disinhibition in the elevated plus-maze. In 5-HT-depleted, nicotine-induced locomotor sensitization was on treatment days 5, 10, and 15, but only on day 15 in the sham-operated rats. Postsensitization, the locomotor stimulatory effects of amphetamine and the dopamine receptor agonists SKF 38,393, apomorphine, and quinpirole were decreased in 5-HT-depleted animals, aneffect that appeared to be more pronounced in nicotine-treated rats. Repeated nicotine treatment sensitized the nicotine-induced elevation of the extracellular accumbal dopamine levels in sham-operated, but not in 5-HT-depleted rats, and was also associated with decreased D-2 autoreceptor function in both nicotine-treated experimental groups. Conclusions: Depletion of brain 5-HT, which produces behavioral disinhibition, may slightly facilitate the overall expression of locomotor sensitization to nicotine and differentially affect the pre- and postsynaptic neuroadaptive events involved in the expression of these phenomena.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:29:47