Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (H-1 MRS) in schizophrenic subjects and normal controls
Autore:
Steel, RM; Bastin, ME; McConnell, S; Marshall, I; Cunningham-Owens, DG; Lawrie, SM; Johnstone, EC; Best, JJK;
Indirizzi:
Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF idlothian, Scotland Univ Edinburgh, Western Gen Hosp, Dept Med Phys & Med Engn, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH42XU Midlothian, Scotland
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 106, anno: 2001,
pagine: 161 - 170
SICI:
0925-4927(20010530)106:3<161:DTI(AP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CURRENT-INDUCED ARTIFACTS; IMAGES; ANISOTROPY; ECHO; ABNORMALITIES;
Keywords:
schizophrenia; frontal lobe; neurons; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Steel, RM Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Kennedy Tower,Morningside Pk, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh Kennedy Tower,Morningside Pk Edinburgh Midlothian Scotland EH10 5HF
Citazione:
R.M. Steel et al., "Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (H-1 MRS) in schizophrenic subjects and normal controls", PSYCH RES-N, 106(3), 2001, pp. 161-170

Abstract

Several proton magnetic resonance spectroscopy(H-1 MRS) studies in schizophrenia have found reduced N-acetyl aspartate (NAA) concentrations in pre-frontal and temporal regions of the brain. Reductions in NAA may reflect abnormalities of neuronal structure (e.g, reduced neuronal density or viability) or abnormalities of neuronal function. Diffusion tensor imaging (DTI) measures diffusion anisotropy, an indicator of the structural integrity of a neuronal tract. Both techniques were used to examine the anatomical basis ofpre-frontal dysfunction in schizophrenia. Ten patients with DSM-IV schizophrenia were compared with 10 healthy controls. H-1 MRS and DTI were performed on a clinical MR system and analysed with a region of interest approach. NAA concentrations and diffusion anisotropy were measured in the same pre-frontal white matter region. Diffusion anisotropy was also measured in a control region (occipital white matter). H-1 MRS revealed non-significant butconsistently reduced NAA concentrations (by 10-15%) in the pre-frontal white matter in schizophrenic subjects. Diffusion anisotropy measures revealedno such differences between schizophrenics and controls. It is concluded that the abnormalities of 'connectivity' reported in brain-imaging studies of schizophrenia may not be attributable to structural abnormalities of white matter and that reduced NAA in the pre-frontal white matter may reflect abnormal function of structurally intact neurons. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:30:16