Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic stimulation in depressed patients. A pilot study
Autore:
Catafau, AM; Perez, V; Gironell, A; Martin, JC; Kulisevsky, J; Estorch, M; Carrio, I; Alvarez, E;
Indirizzi:
Hosp Sant Pau, Dept Nucl Med, Barcelona 08025, Spain Hosp Sant Pau Barcelona Spain 08025 ept Nucl Med, Barcelona 08025, Spain Hosp Sant Pau, Dept Psychiat, Barcelona 08025, Spain Hosp Sant Pau Barcelona Spain 08025 ept Psychiat, Barcelona 08025, Spain Hosp Sant Pau, Dept Neurol, Barcelona 08025, Spain Hosp Sant Pau Barcelona Spain 08025 Dept Neurol, Barcelona 08025, Spain
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 106, anno: 2001,
pagine: 151 - 160
SICI:
0925-4927(20010530)106:3<151:SMOCAC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; BLOOD-FLOW; PREFRONTAL CORTEX; MAJOR DEPRESSION; DOUBLE-BLIND; RESISTANT DEPRESSION; BASE-LINE; PERFUSION; BRAIN; ABNORMALITIES;
Keywords:
repetitive transcranial magnetic stimulation (rTMS); depression; single photon emission computed tomography; (SPECT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Catafau, AM Hosp Sant Pau, Dept Nucl Med, Pare Claret 167, Barcelona 08025, Spain Hosp Sant Pau Pare Claret 167 Barcelona Spain 08025 25, Spain
Citazione:
A.M. Catafau et al., "SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic stimulation in depressed patients. A pilot study", PSYCH RES-N, 106(3), 2001, pp. 151-160

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is being investigated as an alternative treatment for depression. However, little is known about the clinical role and the neurophysiological mechanisms of the action of rTMS in these patients. In this study, Tc-99m-HMPAO single photon emission computed tomography (SPECT) was used to map the effects of left dorsolateral prefrontal rTMS on prefrontal activity in seven patients who met DSM-IV criteria for major depression resistant to pharmacological treatment. rTMS consisted of 30 trains of 2-s duration stimuli (20 Hz, 90% of motor threshold), separated by 30-s pauses. Each patient underwent three SPECTs: at baseline; during the first rTMS; and 1 week after 10 daily sessions of rTMS. Regional cerebral blood flow (rCBF) of each cerebral region was normalized to the rCBF value in the cerebellum and relative changes in normalized rCBF wereaddressed using a region-of-interest analysis. The Hamilton Depression Rating Scale (HDRS) was used for clinical evaluation before and after rTMS. A significant rCBF increase after the 10 sessions of rTMS was found in the left prefrontal region (MANOVA F = 5.29, d.f. = 2,10, P = 0.027), but no significant rCBF changes were found during the first rTMS session,The remainingcerebral regions showed no significant rCBF changes at any time. Only two patients showed a clinic;ll improvement after rTMS, with 50% reduction of the initial HDRS score. The study was repeated under placebo conditions (identical design but addressing coil discharges to the air) in these two patients, who failed to show any rCBF increase during sham-rTMS. No relationshipwas found between the percentage of left prefrontal rCBF change and the clinical findings. In conclusion, rTMS of the left prefrontal cortex induces a significant rCBF increase in this region, despite the limited clinical effect in our sample: of depressed patients. Cerebral perfusion SPECT is a useful tool to map cerebral activity changes induced by rTMS. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:20:22