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Titolo:
Rod-cone interactions: Developmental and clinical significance
Autore:
Mohand-Said, S; Hicks, D; Leveillard, T; Picaud, S; Porto, F; Sahel, JA;
Indirizzi:
Univ Strasbourg 1, Hop Univ Strasbourg, Clin Med A,Lab Physiopathol Cellulaire & Mol Reti, INSERM,EMI 99 8, F-67091 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67091 , F-67091 Strasbourg, France
Titolo Testata:
PROGRESS IN RETINAL AND EYE RESEARCH
fascicolo: 4, volume: 20, anno: 2001,
pagine: 451 - 467
SICI:
1350-9462(200107)20:4<451:RIDACS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; DOMINANT RETINITIS-PIGMENTOSA; RETINOL-BINDING PROTEIN; POLARITY GENE HEDGEHOG; PHOTORECEPTOR DEGENERATION; MACULAR DEGENERATION; RHODOPSIN MUTATION; TRANSGENIC MICE; SONIC-HEDGEHOG; EGF RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Sahel, JA Univ Strasbourg 1, Hop Univ Strasbourg, Clin Med A,Lab Physiopathol Cellulaire & Mol Reti, INSERM,EMI 99 8, 1 Pl Hop, F-67091 Strasbourg, France Univ Strasbourg 1 1 Pl Hop Strasbourg France F-67091 rg, France
Citazione:
S. Mohand-Said et al., "Rod-cone interactions: Developmental and clinical significance", PROG RET EY, 20(4), 2001, pp. 451-467

Abstract

During the last decade, numerous research reports have considerably improved our knowledge about the physiopathology of retinal degenerations. Three non-mutually exclusive general areas dealing with therapeutic approaches have been proposed; gene therapy, pharmacology and retinal transplantations. The first approach involving correction of the initial mutation, will need a great deal of time and further development before becoming a therapeutic tool in human clinical practice. The observation that cone photoreceptors, even those seemingly unaffected by any described anomaly, die secondarily to rod disappearance related to mutations expressed specifically in the latter, led us to study the interactions between these two photoreceptor populations to search for possible causal links between rod degeneration and conedeath. These in vivo and in vitro studies suggest that paracrine interactions between both cell types exist and that rods are necessary for continuedcone survival. Since the role of cones in visual perception is essential, pending the identification of the factors mediating these interactions underway, rod replacement by transplantation and/or neuroprotection by trophic factors or alternative pharmacological means appear as promising approachesfor limiting secondary cone loss in currently untreatable blinding conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:36:10