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Titolo:
Shaping of a scroll wave filament by cardiac fibers - art. no. 061901
Autore:
Berenfeld, O; Wellner, M; Jalife, J; Pertsov, AM;
Indirizzi:
SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY 13210 USA SUNY UpstateMed Univ Syracuse NY USA 13210 macol, Syracuse, NY 13210 USA Syracuse Univ, Dept Phys, Syracuse, NY 13244 USA Syracuse Univ Syracuse NY USA 13244 iv, Dept Phys, Syracuse, NY 13244 USA
Titolo Testata:
PHYSICAL REVIEW E
fascicolo: 6, volume: 6306, anno: 2001,
parte:, 1
pagine: 1901 -
SICI:
1063-651X(200106)6306:6<1901:SOASWF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL CONTINUOUS MYOCARDIUM; VENTRICULAR ARRHYTHMIAS; ROTATIONAL ANISOTROPY; FIBRILLATION; MECHANISM; DYNAMICS; REENTRY; PATTERNS; ISCHEMIA; MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
--discip_EC--
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Berenfeld, O SUNY Upstate Med Univ, Dept Pharmacol, Syracuse, NY 13210 USASUNY Upstate Med Univ Syracuse NY USA 13210 se, NY 13210 USA
Citazione:
O. Berenfeld et al., "Shaping of a scroll wave filament by cardiac fibers - art. no. 061901", PHYS REV E, 6306(6), 2001, pp. 1901

Abstract

Scroll waves of electrical excitation in heart tissue are implicated in the development of lethal cardiac arrhythmias. Here we study the relation between the geometry of myocardia fibers and the equilibrium shape of a scrollwave filament. Our theory accommodates a wide class of myocardial models with spatially varying diffusivity tensor, adjusted to fit fiber geometry. We analytically predict the exact equilibrium shapes of the filaments. The major conclusion is that the filament shape is a compromise between a straight line and full alignment with the fibers. The degree of alignment increases with the anisotropy ratio. The results, being purely geometrical, are independent of details of ionic membrane mechanisms. Our theoretical predictions have been verified to excellent accuracy by numerically simulating the stable equilibration of a scroll filament in a model of the FitzHugh-Nagumotype.

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Documento generato il 20/01/20 alle ore 07:23:50