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Titolo:
T-cell anergy and peripheral T-cell tolerance
Autore:
Lechler, R; Chai, JG; Marelli-Berg, F; Lombardi, G;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, LondonW12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1409, volume: 356, anno: 2001,
pagine: 625 - 637
SICI:
0962-8436(20010529)356:1409<625:TAAPTT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE PHOSPHORYLATION; ANTIGEN-PRESENTING CELLS; CLONAL ANERGY; IN-VIVO; EFFECTOR FUNCTION; SELF-TOLERANCE; LYMPHOCYTES-T; INDUCE TOLERANCE; TRANSGENIC MICE; VIRAL-INFECTION;
Keywords:
T cells; tolerance; anergy; regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Lechler, R Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, Hammersmith Campus,Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Hammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
R. Lechler et al., "T-cell anergy and peripheral T-cell tolerance", PHI T ROY B, 356(1409), 2001, pp. 625-637

Abstract

The discovery that T-cell recognition of antigen can have distinct outcomes has advanced understanding of peripheral T-cell tolerance, and opened up new possibilities in immunotherapy. Anergy is one such outcome, and resultsfrom partial T-cell activation. This can arise either due to subtle alteration of the antigen, leading to a lower-affinity cognate interaction, or due to a lack of adequate co-stimulation. The signalling defects in anergic Tcells are partially defined, and suggest that T-cell receptor (TCR) proximal, as well as downstream defects negatively regulate the anergic T cell's ability to be activated. Most importantly, the use of TCR-transgenic mice was provided compelling evidence that anergy is an in vivo phenomenon, and not merely an in vitro artefact. The:je findings raise the question as to whether anergic T cells have any biological function. Studies in rodents and in man suggest that anergic T cells acquire regulatory properties; the regulatory effects of anergic T cells require cell to cell contact, and appear to be mediated by inhibition of antigen-presenting cell immunogenicity. Close similarities exist between anergic T cells, and the recently defined CD4(+)CD25(+) population of spontaneously arising regulatory cells that serve to inhibit autoimmunity in mice. Taken together, these findings suggest that a spec- tl um of regulatory T cells exists. At one end of the spectrum are cells, such as anergic and CD4(+)CD25(+) T cells, which regulate via cell-to-cell contact. At the other end of the spectrum are cells which secrete antiinflammatory cytokines such as interleukin 10 and transforming growth factor-beta. Tile challenge is to devise strategies that reliably induce T-cell anergy in vivo, as a means of inhibiting immunity to allo- and autoantigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:18:59