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Titolo:
Ventricular fibrillation: evolution of the multiple-wavelet hypothesis
Autore:
Panfilov, A; Pertsov, A;
Indirizzi:
Univ Utrecht, Dept Theoret Biol, NL-3584 CH Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CH 3584 CH Utrecht, Netherlands SUNY Hlth Sci Ctr, Dept Pharmacol, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr Syracuse NY USA 13210 Pharmacol, Syracuse, NY 13210 USA
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
fascicolo: 1783, volume: 359, anno: 2001,
pagine: 1315 - 1325
SICI:
1364-503X(20010615)359:1783<1315:VFEOTM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-DIMENSIONAL CONTINUOUS MYOCARDIUM; ROTATING CHEMICAL WAVES; EXCITABLE MEDIA; SPIRAL BREAKUP; ELECTRICAL RESTITUTION; CARDIAC FIBRILLATION; SCROLL WAVES; MODEL; DYNAMICS; ORGANIZATION;
Keywords:
cardiac arrhythmias; spiral waves; fibrillation; chaos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Panfilov, A Univ Utrecht, Dept Theoret Biol, Padualaan 8, NL-3584 CH Utrecht, Netherlands Univ Utrecht Padualaan 8 Utrecht Netherlands NL-3584 CH lands
Citazione:
A. Panfilov e A. Pertsov, "Ventricular fibrillation: evolution of the multiple-wavelet hypothesis", PHI T ROY A, 359(1783), 2001, pp. 1315-1325

Abstract

Every heartbeat is preceded by an electrical wave of excitation that rapidly propagates through the cardiac muscle, triggering mechanical contractions of cardiac myocytes. Abnormal propagation of this wave causes severe cardiac arrhythmias. The most dangerous of these is ventricular fibrillation, the leading cause of sudden death in the industrialized world. It is well established that ventricular fibrillation is a result of turbulent; propagation of the electrical excitation wave. However, despite more than a century of investigation, the precise mechanism of its initiation and maintenance remains largely unknown. Novel, experimental tools for the visualization of the excitation wave as well as advanced three-dimensional computer models of the heart, which have become available in recent years, have intensified attempts to solve the puzzle of ventricular fibrillation. These efforts have revealed significantly different manifestations of ventricular fibrillation, suggesting that multiple mechanisms are responsible for this arrhythmia. Several new hypotheses have been put forward recently that deviate considerably from Moe's standard hypothesis of fibrillation, which has dominated the field for almost four decades. One of the hypotheses that has been mostactively discussed is the spiral-breakup (also called the restitution) hypothesis. This hypothesis may lead to a breakthrough in our understanding ofthe factors that; cause this deadly arrhythmia and provide a constructive approach to the development of efficient antifibrillatory drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:23:22