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Titolo:
Mechanoelectric feedback in cardiac cells
Autore:
Kohl, P; Sachs, F;
Indirizzi:
Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England SUNY Buffalo, Dept Physiol & Biophys Sci, Buffalo, NY 14241 USA SUNY Buffalo Buffalo NY USA 14241 ol & Biophys Sci, Buffalo, NY 14241 USA
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
fascicolo: 1783, volume: 359, anno: 2001,
pagine: 1173 - 1185
SICI:
1364-503X(20010615)359:1783<1173:MFICC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED ION CHANNELS; PIG VENTRICULAR MYOCYTES; INTRACELLULAR CALCIUM TRANSIENTS; CONTRACTION-EXCITATION FEEDBACK; SPONTANEOUS PACEMAKER ACTIVITY; SENSITIVE POTASSIUM CHANNELS; STRETCH-INDUCED INCREASE; SINOATRIAL NODE CELLS; MECHANICAL STRETCH; MYOCARDIAL STRETCH;
Keywords:
heart; electrophysiology; mechanoelectric feedback; stretch-activated channel; mathematical model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Kohl, P Univ Oxford, Physiol Lab, Parks Rd, Oxford OX1 3PT, England Univ Oxford Parks Rd Oxford England OX1 3PT ford OX1 3PT, England
Citazione:
P. Kohl e F. Sachs, "Mechanoelectric feedback in cardiac cells", PHI T ROY A, 359(1783), 2001, pp. 1173-1185

Abstract

Cardiac electrophysiology is affected by cardiac mechanics. The input fromthe heart's mechanical environment to its electrical behaviour has been termed mechano-electric feedback (MEF) and is well documented by more than a century of clinical observations on mechanical modulation of heart rate andrhythm. The mechanisms underlying cardiac MEF have been investigated for only a few decades and include stretch activation of ion channels and mechanical. modulation of cellular Ca2+ handling. This review briefly outlines the scope and limitations of current experimental insight and its implementation in mathematical models of cardiac cellular activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:33:49