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Titolo:
Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling
Autore:
Boyett, MR; Zhang, H; Garny, A; Holden, AV;
Indirizzi:
Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
fascicolo: 1783, volume: 359, anno: 2001,
pagine: 1091 - 1110
SICI:
1364-503X(20010615)359:1783<1091:COTPAO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECTIFIER POTASSIUM CURRENT; PIG VENTRICULAR MYOCYTES; SUSTAINED INWARD CURRENT; MATHEMATICAL-MODELS; EXCHANGE CURRENT; KINASE-C; CELLS; CALCIUM; RAT; RELEASE;
Keywords:
sinoatrial node; intracellular Ca2+ handling; pacemaker activity; action potential; Ca2+-dependent ionic currents; computer modelling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Boyett, MR Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds Leeds W Yorkshire England LS2 9JT orkshire, England
Citazione:
M.R. Boyett et al., "Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling", PHI T ROY A, 359(1783), 2001, pp. 1091-1110

Abstract

The possible effects of intracellular Ca2+ on the pacemaker of the heart, the sinoatrial node, are reviewed. In mammalian sinoatrial node, reduction or abolition of the intracellular Ca2+ transient by ryanodine, sarcoplasmicreticulum Ca2+ pump block or 1,2-bis(2.-aminophenoxy)ethane-N,N,N ' ,N ' -tetraacetic acid (BAPTA) reduces the spontaneous rate by 21-32%, whereas inamphibian sinus venosus it abolishes spontaneous activity. In rabbit sinoatrial node, ryanodine/BAPTA reduces the T-type Ca2+ current (i(Ca,T)), perhaps slows inactivation of the L-type Ca2+ current (i(Ca,L)), reduces the inward Na+-Ca2+ exchange current (i(NaCa)), and reduces the rapid and slow delayed rectifier K+ currents (i(K,r) and i(K,s), respectively). Other evidence shows that a reduction of intracellular Ca inhibits the hyperpolarization-activated current (i(f)). These putative intracellular Ca2+-dependent changes in ionic currents have been incorporated into different models of rabbit sinoatrial node action potentials. In the models, block of the Ca2+ transient reduced the spontaneous rate by 24 and 26% in the central and peripheral models of Zhang and others, 13% in the Oxsoft model (Noble et al.), 9% in the model of Wilders and others, and 41% in the model of Demir and others. In all models, the reduction in rate was not primarily the result of thedecrease in i(NaCa), but instead the combination of all changes in ionic currents.

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Documento generato il 06/04/20 alle ore 07:04:26