Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Indications for pediatric intestinal transplantation: A position paper of the American Society of Transplantation
Autore:
Kaufman, SS; Atkinson, JB; Bianchi, A; Goulet, OJ; Grant, D; Langnas, AN; McDiarmid, SV; Mittal, N; Reyes, J; Tzakis, AG;
Indirizzi:
Creighton Univ, Joint Sect Pediat Gastroenterol, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 diat Gastroenterol, Omaha, NE 68178 USA Univ Nebraska, Med Ctr, Omaha, NE USA Univ Nebraska Omaha NE USAUniv Nebraska, Med Ctr, Omaha, NE USA Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA St Marys Hosp, Neonatal Surg Unit, Manchester M13 0JH, Lancs, England St Marys Hosp Manchester Lancs England M13 0JH er M13 0JH, Lancs, England Univ Hosp Necker Enfants Malades, F-75252 Paris, France Univ Hosp Necker Enfants Malades Paris France F-75252 5252 Paris, France Univ Toronto, Dept Surg, Toronto, ON, Canada Univ Toronto Toronto ON Canada v Toronto, Dept Surg, Toronto, ON, Canada Univ Nebraska, Med Ctr, Dept Surg, Organ Transplantat Program, Omaha, NE USA Univ Nebraska Omaha NE USA rg, Organ Transplantat Program, Omaha, NE USA Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Miami Univ, Sect Pediat Gastroenterol, Miami, FL USA Miami Univ Miami FL USA i Univ, Sect Pediat Gastroenterol, Miami, FL USA Univ Pittsburgh, Thomas Starzl Transplantat Inst, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Transplantat Inst, Pittsburgh, PA USA Miami Univ, Sect Transplantat Surg, Miami, FL USA Miami Univ Miami FL USA iami Univ, Sect Transplantat Surg, Miami, FL USA
Titolo Testata:
PEDIATRIC TRANSPLANTATION
fascicolo: 2, volume: 5, anno: 2001,
pagine: 80 - 87
SICI:
1397-3142(200104)5:2<80:IFPITA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-BOWEL SYNDROME; TOTAL PARENTERAL-NUTRITION; FAMILIAL ADENOMATOUS POLYPOSIS; CLINICOPATHOLOGICAL SURVEY; DESMOID TUMORS; CHILDREN; LIVER; CHOLESTASIS; FAILURE; ADAPTATION;
Keywords:
child; indications; intestinal transplantation; liver failure; short bowel syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufman, SS Creighton Univ, Joint Sect Pediat Gastroenterol, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 nterol, Omaha, NE 68178 USA
Citazione:
S.S. Kaufman et al., "Indications for pediatric intestinal transplantation: A position paper of the American Society of Transplantation", PEDIAT TRAN, 5(2), 2001, pp. 80-87

Abstract

Parenteral nutrition represents standard therapy for children with short bowel syndrome and other causes of intestinal failure. Most infants with short bowel syndrome eventually wean from parenteral nutrition, and most of those Those do not wean tolerate parenteral nutrition for protracted periods. However, a subset of children with intestinal failure remaining dependent on parenteral nutrition will develop lift-threatening complications arisingfrom therapy. Intestinal transplantation (Ts) can now be recommended for this select group. Life-threatening complications warranting consideration of intestinal Tx include parental nutrition-associated liver disease, recurrent sepsis, and threatened loss of central venous access. Because a critical shortage of donor organs exists, waiting times for intestinal Tx are prolonged. Therefore, it is essential that children with life-threatening complications of intestinal failure and parental al nutrition therapy be identified comparatively early, i.e. in time to receive suitable donor organs before they become critically ill. Children with liver dysfunction should be considered for isolated intestinal Tx before in-eversible, advanced bridging fibrosis or cirrhosis supervenes. for which a combined liver and intestinaltransplant is necessary. Irreversible liver disease is suggested by hyper bilirubinemia persisting beyond 3-4 months of age combined with features ofportal hypertension such as splenomegaly, thrombocytopenia, or prominent superficial abdominal veins; esophageal varices, ascites, and impaired synthetic function are not always present. Death resulting from complications ofliver failure is especially common during the wait for a combined liver and intestinal transplant, and survival following combined liver and intestinal Tx is probably lower than following an isolated intestinal transplant. The incidence of morbidity and mortality following intestinal Tx is: greaterthan that following liver or kidney Tx, but long-term survival following intestinal Tx is now at least 50-60%. It is probable that outcomes shall improve in the future with continued refinements in operative technique and post-operative management, including immunosuppression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:30:23