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Titolo:
Echocardiographic findings of hypertrophic cardiomyopathy in children after orthotopic liver transplantation
Autore:
Chang, RKR; McDiarmid, SV; Alejos, JC; Drant, SE; Klitzner, TS;
Indirizzi:
Harbor UCLA Med Ctr, Div Cardiol, Dept Pediat, Torrance, CA 90509 USA Harbor UCLA Med Ctr Torrance CA USA 90509 Pediat, Torrance, CA 90509 USA Univ Calif Los Angeles, Sch Med, Dept Pediat, Div Gastroenterol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Pediat, Div Cardiol, Los Angeles, CA90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA90024 USA
Titolo Testata:
PEDIATRIC TRANSPLANTATION
fascicolo: 3, volume: 5, anno: 2001,
pagine: 187 - 191
SICI:
1397-3142(200106)5:3<187:EFOHCI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TACROLIMUS FK506; POPULATION;
Keywords:
tacrolimus (FK506); cyclosporin A; immunosuppression; hypertrophic cardiomyopathy; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, RKR Harbor UCLA Med Ctr, Div Cardiol, Dept Pediat, 1000 W Carson St, Torrance,CA 90509 USA Harbor UCLA Med Ctr 1000 W Carson St Torrance CA USA 90509 USA
Citazione:
R.K.R. Chang et al., "Echocardiographic findings of hypertrophic cardiomyopathy in children after orthotopic liver transplantation", PEDIAT TRAN, 5(3), 2001, pp. 187-191

Abstract

This study was carried out to compare echocardiographic findings of children taking tacrolimus and cyclosporin A (CsA) after orthotopic liver transplantation (OLT). Echocardiograms of 19 children were reviewed during hospitalizations after OLT, and echocardiograms were performed on 23 children who returned to the clinic for a routine follow-up visit after OLT. Measurements were made of the left ventricle (LV) end-diastolic dimension, and of the thickness of the LV free wall (LVFW) and the inter-ventricular septum (IVS). From these measurements, the LV mass was calculated. LV outflow; gradientwas measured by using Doppler interrogation. Comparisons were made betweenpatients on CsA and patients on tacrolimus, Children with hypertrophic cardiomyopathy (HCM) were identified. Two patients from the in-patient tacrolimus group were found to have HCM. These two patients had asymmetric septal hypertrophy with dynamic LV outflow obstruction and were successfully treated with propranolol, with or without discontinuing tacrolimus. In the out-patient studies, there was no difference in LVFW and IVS thickness, or LV mass index, between children on CsA and children on tacrolimus. Hence, tacrolimus is associated with the development of HCM in children. The effect of tacrolimus on HCM development may be acute and temporary. More data are needed to determine the incidence of HCM in children on tacrolimus therapy and to establish guidelines for clinicians who followup these children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:25:39