Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Methyl CpG binding proteins: coupling chromatin architecture to gene regulation
Autore:
Wade, PA;
Indirizzi:
Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 t Pathol & Lab Med, Atlanta, GA 30322 USA
Titolo Testata:
ONCOGENE
fascicolo: 24, volume: 20, anno: 2001,
pagine: 3166 - 3173
SICI:
0950-9232(20010528)20:24<3166:MCBPCC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL REPRESSOR MECP2; HISTONE DEACETYLASE COMPLEX; LINKED MENTAL-RETARDATION; RETT-SYNDROME MUTATIONS; DNA METHYLATION; CHROMOSOMAL PROTEIN; DOMAIN; MBD4; METHYLTRANSFERASES; GIRLS;
Keywords:
DNA methylation; MeCP2; Rett syndrome; histone deacetylase; chromatin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Wade, PA Emory Univ, Sch Med, Dept Pathol & Lab Med, Woodruff Mem Res Bldg,Room 7105B,1639 Pierce Dr, Atlanta, GA 30322 USA Emory Univ Woodruff Mem Res Bldg,Room 7105B,1639 Pierce Dr Atlanta GA USA 30322
Citazione:
P.A. Wade, "Methyl CpG binding proteins: coupling chromatin architecture to gene regulation", ONCOGENE, 20(24), 2001, pp. 3166-3173

Abstract

A correlation between DNA methylation and transcriptional silencing has existed for many Sears. Recently, substantial progress has been reported in the search for proteins that interpret the regulatory information inherent in DNA methylation and translate this information into functional states, resulting in the identification of a family of highly conserved proteins, theMBD family. Direct connections between these proteins and histone modification enzymes have emerged as a common theme, implying that DNA methylation exerts its effects primarily through repressive chromatin architecture. Recent structural determinations of the DNA binding domain of two MBD family members, MeCP2 and MBD1, provide a framework to model the interactions of this family with DNA, Comparative sequence analysis and experimental DNA binding data can be interpreted using this structural framework allowing one tocontrast the members of the MBD family with each other and to predict the properties of new family members. The identification of mutations in MeCP2,the founding member of this family, as causal for the neurological developmental disorder Rett Syndrome provides additional information regarding amino acid residues crucial to the functions of this interesting protein family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:46:24