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Titolo:
When the SWI/SNF complex remodels ... the cell cycle
Autore:
Muchardt, C; Yaniv, M;
Indirizzi:
Inst Pasteur, Dept Biotechnol, CNRS, URA1644,Unite Virus Oncogenes, F-75724 Paris 15, France Inst Pasteur Paris France 15 e Virus Oncogenes, F-75724 Paris 15, France
Titolo Testata:
ONCOGENE
fascicolo: 24, volume: 20, anno: 2001,
pagine: 3067 - 3075
SICI:
0950-9232(20010528)20:24<3067:WTSCR.>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SWI-SNF COMPLEX; SACCHAROMYCES-CEREVISIAE; GLUCOCORTICOID RECEPTOR; C-MYC; TRANSCRIPTIONAL ACTIVATION; RETINOBLASTOMA PROTEIN; DROSOPHILA-BRAHMA; GCN5 BROMODOMAIN; HIV-1 INTEGRASE; GROWTH ARREST;
Keywords:
N-CoR; HDAC; cyclin A; cyclin E; G0;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Muchardt, C Inst Pasteur, Dept Biotechnol, CNRS, URA1644,Unite Virus Oncogenes, 25 RueDocteur Roux, F-75724 Paris 15, France Inst Pasteur 25 Rue Docteur Roux Paris France 15 s 15, France
Citazione:
C. Muchardt e M. Yaniv, "When the SWI/SNF complex remodels ... the cell cycle", ONCOGENE, 20(24), 2001, pp. 3067-3075

Abstract

Mammalian cells contain several chromatin-remodeling complexes associated with the Brm and Brg1 helicase-like proteins. These complexes likely represent the functional homologs of the SWI/SNF and RSC complexes found in Saccharomyces cerevisiae. The mammalian chromatin-remodeling complexes are involved in both activation and repression of a variety of genes. Several lines of evidence also indicate that they play a specific role in the regulation of cell growth. Brm is down-regulated by ras signaling and its forced reexpression suppresses transformation by this oncogene, Besides, the Brg1 gene is silenced or mutated in several tumors cell lines and a Brg1-associated complex was recently found to co-purify with BRCA1, involved in breast and ovarian cancers, Finally, the gene encoding SNF5/Ini1, a subunit common to all mammalian SWI/SNF complexes, is inactivated in rhabdoid sarcomas, a veryaggressive form of pediatric cancer, The current review will address observations made upon inactivation of Brm, Brg1 and SNF5/Ini1 by homologous recombination in the mouse, as well as the possible implication of these factors in the regulation of the Retinoblastoma pRb-mediated repression of the transcription factor E2F.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 17:10:10