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Titolo:
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription
Autore:
Dilworth, FJ; Chambon, P;
Indirizzi:
Coll France, ULP, INSERM, CNRS,IGBMC, F-67404 Illkirch, CU Strasbourg, France Coll France Illkirch CU Strasbourg France F-67404 , CU Strasbourg, France
Titolo Testata:
ONCOGENE
fascicolo: 24, volume: 20, anno: 2001,
pagine: 3047 - 3054
SICI:
0950-9232(20010528)20:24<3047:NRCTAO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE RECEPTOR; LIGAND-BINDING DOMAIN; RETINOID-X-RECEPTOR; RNA-POLYMERASE-II; PROMOTER IN-VIVO; ESTROGEN-RECEPTOR; HISTONE ACETYLTRANSFERASES; GLUCOCORTICOID RECEPTOR; ACTIVATE TRANSCRIPTION; DEPENDENT ACTIVATION;
Keywords:
nuclear receptors; histone acetyltransferases; ATP-dependent chromatin remodeling coactivators; in vitro transcription; RAR/RXR heterodimers;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Chambon, P Coll France, ULP, INSERM, CNRS,IGBMC, BP163, F-67404 Illkirch, CU Strasbourg, France Coll France BP163 Illkirch CU Strasbourg France F-67404 France
Citazione:
F.J. Dilworth e P. Chambon, "Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription", ONCOGENE, 20(24), 2001, pp. 3047-3054

Abstract

Recent advances in the field of in vitro chromatin assembly have led to invitro transcription systems which reproduce in the test tube, in vivo characteristics of ligand-dependent transcriptional activation by nuclear receptors. Dissection of these systems has begun to provide us with information concerning the underlying molecular mechanisms. Through recruitment of coactivator proteins, nuclear receptors act first to remodel chromatin within the promoter region and then to recruit the transcriptional machinery to thepromoter region in order to initiate transcription. Here we present a possible sequential mechanism for ligand-dependent transcriptional activation by nuclear receptors and discuss the in vitro and in vivo data that support this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:28:17