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Titolo:
Glucocorticoid receptor-mediated chromatin remodeling in vivo
Autore:
Deroo, BJ; Archer, TK;
Indirizzi:
NIEHS, Chromatin & Gene Express Sect, Reprod & Dev Toxicol Lab, NIH, Res Triangle Pk, NC 27709 USA NIEHS Res Triangle Pk NC USA 27709 ab, NIH, Res Triangle Pk, NC 27709 USA
Titolo Testata:
ONCOGENE
fascicolo: 24, volume: 20, anno: 2001,
pagine: 3039 - 3046
SICI:
0950-9232(20010528)20:24<3039:GRCRIV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BREAST-CANCER; TUMOR VIRUS PROMOTER; LINKER HISTONE H1; TRANSCRIPTION IN-VIVO; YEAST SWI/SNF COMPLEX; SWI-SNF COMPLEX; GENE-EXPRESSION; MMTV PROMOTER; RAPID EXCHANGE; LIVING CELLS;
Keywords:
glucocorticoid receptor; chromatin; mouse mammary tumor virus; BRG1; Swi/Snf; histone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Archer, TK NIEHS, Chromatin & Gene Express Sect, Reprod & Dev Toxicol Lab,NIH, POB 12233, Res Triangle Pk, NC 27709 USA NIEHS POB 12233 Res TrianglePk NC USA 27709 e Pk, NC 27709 USA
Citazione:
B.J. Deroo e T.K. Archer, "Glucocorticoid receptor-mediated chromatin remodeling in vivo", ONCOGENE, 20(24), 2001, pp. 3039-3046

Abstract

The compaction of DNA into chromatin provides an additional level of gene regulation in eukaryotes that may not be available to prokaryotes. When packaged as chromatin, most promoters are transcriptionally repressed, and transcription factors have reduced access to their binding sites. The glucocorticoid receptor (GR) is a ligand-activated transcription factor that regulates the activity of genes involved in many physiological processes. To regulate eukaryotic genes, the GR binds to target sites within promoter regionsof genes assembled as chromatin, This interaction alters the nucleosomal architecture to allow binding of other transcription factors, and formation of the preinitiation complex. The mouse mammary tumor virus (MMTV) promoterhas been used extensively as a model to explore the processes by which theGR remodels chromatin and activates transcription. Significant progress has been made in our understanding of the mechanisms used by the GR to modifychromatin structure, and the limits placed on the GR by post-translationalmodifications of histones, We will describe recent developments in the processes used by the GR to activate transcription in vivo via chromatin remodeling complexes, histone H1 phosphorylation, and recruitment of diverse coactivators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:54:14