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Titolo:
Chromatin remodeling and transcriptional activation: the cast (in order ofappearance)
Autore:
Urnov, FD; Wolffe, AP;
Indirizzi:
Sangamo Biosci, Pt Richmond Tech Ctr, Richmond, CA 94804 USA Sangamo Biosci Richmond CA USA 94804 ond Tech Ctr, Richmond, CA 94804 USA
Titolo Testata:
ONCOGENE
fascicolo: 24, volume: 20, anno: 2001,
pagine: 2991 - 3006
SICI:
0950-9232(20010528)20:24<2991:CRATAT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE RECEPTOR; YEAST SWI/SNF COMPLEX; IFN-BETA ENHANCEOSOME; CORE HISTONE ACETYLATION; IN-VIVO; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; GLUCOCORTICOID RECEPTOR; NUCLEOSOMAL DNA; SWI-SNF;
Keywords:
chromatin; transcription; histone deacetylase; histone acetyltransferase; chromatin remodeling;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
150
Recensione:
Indirizzi per estratti:
Indirizzo: Urnov, FD Sangamo Biosci, Pt Richmond Tech Ctr, 501 Canal Blvd,Suite A100,Richmond,CA 94804 USA Sangamo Biosci 501 Canal Blvd,Suite A100 Richmond CAUSA 94804 A
Citazione:
F.D. Urnov e A.P. Wolffe, "Chromatin remodeling and transcriptional activation: the cast (in order ofappearance)", ONCOGENE, 20(24), 2001, pp. 2991-3006

Abstract

The number of chromatin modifying and remodeling complexes implicated in genome control is growing faster than our understanding of the functional roles they play. We discuss recent in vitro experiments with biochemically defined chromatin templates that illuminate new aspects of action by histone acetyltransferases and ATP-dependent chromatin remodeling engines in facilitating transcription. We review a number of studies that present an 'ordered recruitment' view of transcriptional activation, according to which various complexes enter and exit their target promoter in a set sequence, and atspecific times, such that action by one complex sets the stage for the arrival of the next one. A consensus emerging from all these experiments is that the joint action by several types of chromatin remodeling machines can lead to a more profound alteration of the infrastructure of chromatin over atarget promoter than could be obtained by these enzymes acting independently. In addition, it appears that in specific cases one type of chromatin structure alteration (e.g., histone hyperacetylation) is contingent upon prior alterations of a different sort (i.e., ATP-dependent remodeling of histone-DNA contacts), The striking differences between the precise sequence of action by various cofactors observed in these studies may be - at least in part - due to differences between the specific promoters studied, and distinct requirements exhibited by specific loci for chromatin remodeling based on their pre-existing nucleoprotein architecture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:26:46