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Titolo:
Preferential conditions for and possible mechanisms of induction of ischemic tolerance by repeated hyperbaric oxygenation in gerbil hippocampus
Autore:
Wada, K; Miyazawa, T; Nomura, N; Tsuzuki, N; Nawashiro, H; Shima, K;
Indirizzi:
JMSDF, Undersea Med Ctr, Kanagawa 2390831, Japan JMSDF Kanagawa Japan 2390831 , Undersea Med Ctr, Kanagawa 2390831, Japan
Titolo Testata:
NEUROSURGERY
fascicolo: 1, volume: 49, anno: 2001,
pagine: 160 - 166
SICI:
0148-396X(200107)49:1<160:PCFAPM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED NEURONAL DEATH; TRANSIENT FOREBRAIN ISCHEMIA; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; CYTOCHROME-C; CELL-DEATH; CEREBRAL-ISCHEMIA; BCL-2; APOPTOSIS; BRAIN;
Keywords:
Bax; Bcl-2; gerbil; hyperbaric oxygen; ischemic tolerance; manganese superoxide dismutase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, K JMSDF, Undersea Med Ctr, Nagase 2-7-1, Kanagawa 2390831, Japan JMSDF Nagase 2-7-1 Kanagawa Japan 2390831 Kanagawa 2390831, Japan
Citazione:
K. Wada et al., "Preferential conditions for and possible mechanisms of induction of ischemic tolerance by repeated hyperbaric oxygenation in gerbil hippocampus", NEUROSURGER, 49(1), 2001, pp. 160-166

Abstract

OBJECTIVE: We reported previously that repeated hyperbaric oxygenation (HBO) as pretreatment induced ischemic tolerance in the gerbil hippocampus. This study was conducted to determine the preferential conditions for induction of ischemic tolerance by HBO and the mechanism of this induction throughimmunohistochemical analysis of Bcl-2, Bar, and manganese superoxide dismutase expression. METHODS: Five-minute forebrain ischemia was produced in gerbils after pretreatment with 2 atmospheres absolute (ATA) HBO once every other day for one, three, or five sessions, 2 ATA hyperbaric air once every other day for five sessions, or 3 ATA HBO once daily for 10 sessions. Histological examinations were then performed. Two days after pretreatment with 2 ATA HBO once every other day for five sessions or with 3 ATA HBO once daily for 10 sessions, sections were analyzed immunohistochemically. RESULTS: Pretreatment with 2 ATA HBO once every other day for three or five sessions induced ischemic tolerance; however, pretreatment with 2 ATA HBOfor one session, 2 ATA hyperbaric air once every other day for five sessions, or 3 ATA HBO once daily for 10 sessions did not. Pretreatment with 2 ATA HBO once every other day for five sessions, but not with 3 ATA HBO once daily for 10 sessions, significantly increased Bcl-2 and manganese superoxide dismutase immunoreactivity in the CA1 sector. CONCLUSION: These results suggest that protection against mitochondrial alterations after ischemia through manganese superoxide dismutase and/or Bcl-2 expression may be related to induction of ischemic tolerance by repeated HBO pretreatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:14:24