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Titolo:
A short period of maternal nutrient restriction in late gestation modifiespituitary-adrenal function in adult guinea pig offspring
Autore:
Lingas, RI; Matthews, SG;
Indirizzi:
Univ Toronto, Dept Physiol, Fac Med, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 c Med, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Obstet & Gynecol, Fac Med, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 c Med, Toronto, ON M5S 1A8, Canada
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 5, volume: 73, anno: 2001,
pagine: 302 - 311
SICI:
0028-3835(200105)73:5<302:ASPOMN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; RECEPTOR MESSENGER-RNA; BRAIN GROWTH-SPURT; ARGININE-VASOPRESSIN; ANTERIOR-PITUITARY; PRENATAL STRESS; BLOOD-PRESSURE; BIRTH-WEIGHT; RAT; ADRENOCORTICOTROPIN;
Keywords:
development; pregnancy; guinea pig; corticotropin; corticotropin-releasing hormone; food restriction; adrenal steroids; adrenal steroid receptors; pro-opiomelanocortin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Matthews, SG Univ Toronto, Dept Physiol, Fac Med, Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto Med Sci Bldg,1 Kings Coll Circle Toronto ON Canada M5S 1A8
Citazione:
R.I. Lingas e S.G. Matthews, "A short period of maternal nutrient restriction in late gestation modifiespituitary-adrenal function in adult guinea pig offspring", NEUROENDOCR, 73(5), 2001, pp. 302-311

Abstract

Altered fetal environment can program the hypophyseal-pituitary-adrenal (HPA) axis development and thus affect endocrine function in later life. We hypothesized that 48 h of maternal nutrient restriction during the period ofmaximal fetal brain growth alters HPA function in adult offspring and leads to modified blood pressure regulation. Pregnant guinea pigs (n = 15) weredeprived of food (water ad libitum) or fed normally (n = 13) on days 50 and 51 of gestation, after which they were all fed normally (birth = 68 days). Carotid artery and jugular vein catheters were implanted in adult guinea pig offspring (day 65). Animals were treated with corticotropin (ACTH(1-24); 0.5 mug/kg), corticotropin-releasing hormone (CRH; 0.5 mug/kg) and insulin (5 units/kg), and pituitary-adrenal responses were measured. Guinea pigs were then euthanized and pituitaries removed for analysis of pro-opiome-lanocortin (POMC) and glucocorticoid receptor (GR) mRNA levels. There was no effect of prenatal treatment on body weight, blood pressure or heart rate. In male offspring, both basal ACTH (p < 0.007) and basal cortisol (p < 0.05)levels were significantly reduced in animals whose mothers had been nutrient restricted (NR). In contrast, in female offspring, basal plasma ACTH wasnot different between offspring from NR mothers and controls; however, basal plasma cortisol concentrations were significantly (p < 0.01) elevated at13.00 h in females born to NR mothers. Responses to HPA challenge were different between offspring from NR mothers and control offspring, and these differences were consistent with alterations in basal adrenocortical function. There was no effect of prenatal treatment on POMC mRNA levels in the pars distalis or pars intermedia. However, GR mRNA levels were significantly (p < 0.05) reduced in adult female offspring born to NR mothers. In conclusion, 48 h of maternal nutrient restriction during pregnancy has a long-term effect on HPA function in adult offspring, and this effect is highly sex specific, but does not result in alteration of blood pressure. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 22/01/20 alle ore 19:12:29