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Titolo:
Dopamine modulation of prefrontal delay activity-reverberatory activity and sharpness of tuning curves
Autore:
Scheler, G; Fellous, JM;
Indirizzi:
Salk Inst Biol Studies, Computat Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA Sloan Ctr Theoret Neurobiol, La Jolla, CA 92037 USA Sloan Ctr Theoret Neurobiol La Jolla CA USA 92037 La Jolla, CA 92037 USA
Titolo Testata:
NEUROCOMPUTING
, volume: 38, anno: 2001,
pagine: 1549 - 1556
SICI:
0925-2312(200106)38:<1549:DMOPDA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY; CORTEX; RECEPTOR; INTERNEURONS; NETWORK; MODEL; TASK;
Keywords:
memory; computational; neuromodulations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fellous, JM Salk Inst Biol Studies, Computat Neurobiol Lab, 10100 N TorreyPines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10100 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
G. Scheler e J.M. Fellous, "Dopamine modulation of prefrontal delay activity-reverberatory activity and sharpness of tuning curves", NEUROCOMPUT, 38, 2001, pp. 1549-1556

Abstract

Recent electrophysiological experiments have shown that dopamine (D1) modulation of pyramidal cells in prefrontal cortex reduces spike frequency adaptation and enhances NMDA transmission. Using four models, from multicompartmental to integrate-and-fire, we examine the effects of these modulations on sustained (delay) activity in a reverberatory network. We find that D1 modulation may enable robust network bistability yielding selective reverberation among cells that code for a particular item or location. We further show that the tuning curve of such cells is sharpened, and that signal-to-noise ratio is increased. We postulate that D1 modulation affects the tuning of "memory fields" and yield efficient distributed dynamic representations. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:15:21