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Titolo:
Relation between neuronal morphology and electrophysiology in the Kainate lesion model of Alzheimer's Disease
Autore:
Nasuto, SJ; Knape, RM; Krichmar, JL; Ascoli, GA;
Indirizzi:
George Mason Univ, Krasnaow Inst Adv Study, Fairfax, VA 22030 USA George Mason Univ Fairfax VA USA 22030 t Adv Study, Fairfax, VA 22030 USA Inst Neurosci, San Diego, CA 92121 USA Inst Neurosci San Diego CA USA 92121 st Neurosci, San Diego, CA 92121 USA George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA George Mason Univ Fairfax VA USA 22030 ept Psychol, Fairfax, VA 22030 USA
Titolo Testata:
NEUROCOMPUTING
, volume: 38, anno: 2001,
pagine: 1477 - 1487
SICI:
0925-2312(200106)38:<1477:RBNMAE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL-NEURONS; KAINIC ACID; NEOCORTICAL NEURONS; DENDRITIC EXTENT; PYRAMIDAL CELLS;
Keywords:
Alzheimer; CA1; computational modeling; dendritic morphology; kainic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ascoli, GA George Mason Univ, Krasnaow Inst Adv Study, MS2A1,4400 Univ Dr,Fairfax, VA 22030 USA George Mason Univ MS2A1,4400 Univ Dr Fairfax VA USA 22030 0 USA
Citazione:
S.J. Nasuto et al., "Relation between neuronal morphology and electrophysiology in the Kainate lesion model of Alzheimer's Disease", NEUROCOMPUT, 38, 2001, pp. 1477-1487

Abstract

This paper describes a computational and statistical study of the influence of morphological changes on the electrophysiological response of neurons from an animal model of Alzheimer's Disease (AD). We combined experimental morphological data from rat hippocampal CA1 pyramidal cells with a well-established model of active membrane properties. Dendritic morphology and the somatic response to simulated current clamp conditions were then compared for cells from the control and the AD group. The computational approach allowed us to single out the influences of neuromorphology on neuronal responseby eliminating the effects of active channel variability. The results did not reveal a simple relationship between morphological changes associated with AD and changes in neural response. However, they did suggest the existence of more complex than anticipated relationships between dendritic morphology and single-cell electrophysiology. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:53:20