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Titolo:
A model of slow plateau-like oscillations based upon the fast Na+ current in a window mode
Autore:
Cymbalyuk, GS; Calabrese, RL;
Indirizzi:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ry Univ, Dept Biol, Atlanta, GA 30322 USA
Titolo Testata:
NEUROCOMPUTING
, volume: 38, anno: 2001,
pagine: 159 - 166
SICI:
0925-2312(200106)38:<159:AMOSPO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEARTBEAT ELEMENTAL OSCILLATOR; MEDICINAL LEECH; NEURONS; INTERNEURONS; DISSECTION;
Keywords:
slow plateau-like oscillations; window current; sodium plateau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Cymbalyuk, GS Emory Univ, Dept Biol, 1510 Clifton Rd, Atlanta, GA 30322 USA Emory Univ 1510 Clifton Rd Atlanta GA USA 30322 GA 30322 USA
Citazione:
G.S. Cymbalyuk e R.L. Calabrese, "A model of slow plateau-like oscillations based upon the fast Na+ current in a window mode", NEUROCOMPUT, 38, 2001, pp. 159-166

Abstract

Divalent ions, which block Ca2+ currents, combined with partial block of outward currents give rise to slow plateau-like oscillations (10-50 s period) with long duration plateaus and long inter-plateau intervals in leech heart interneurons (Opdyke, Calabrese, J. Comp. Physiol. 175 (1994) 781-789. ) We present a simplified mathematical model that replicates the main characteristics of these observations and suggests an underlying biophysical mechanism. A model containing transient Na+ current (I-Na), leakage and outward currents can generate oscillations with long plateau duration. The plateausarise from a window mode of I-Na and do not require noninactivating Na+ current (I-Na). The long inter-plateau intervals are produced reliably after including I-p. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:35:55