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Titolo:
The role of protein kinase C in the biochemical pathways of classical conditioning
Autore:
Yang, KH; Kotaleski, JH; Blackwell, KT;
Indirizzi:
George Mason Univ, Krasnow Inst Adv Studies, Fairfax, VA 22030 USA George Mason Univ Fairfax VA USA 22030 Adv Studies, Fairfax, VA 22030 USA George Mason Univ, Sch Computat Sci, Fairfax, VA 22030 USA George Mason Univ Fairfax VA USA 22030 omputat Sci, Fairfax, VA 22030 USA
Titolo Testata:
NEUROCOMPUTING
, volume: 38, anno: 2001,
pagine: 79 - 85
SICI:
0925-2312(200106)38:<79:TROPKC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; CEREBELLAR PURKINJE-CELL; ACTIVE MEMBRANE MODEL; ARACHIDONIC-ACID; SIMULATION; SLICE; PKC;
Keywords:
protein kinase C (PKC) activation; classical conditioning; arachidonic acid (AA); diacylglycerol (DAG);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Blackwell, KT George Mason Univ, Krasnow Inst Adv Studies, MS 5C3, Fairfax, VA 22030 USA George Mason Univ MS 5C3 Fairfax VA USA 22030 , VA 22030 USA
Citazione:
K.H. Yang et al., "The role of protein kinase C in the biochemical pathways of classical conditioning", NEUROCOMPUT, 38, 2001, pp. 79-85

Abstract

Evidence suggests that protein kinase C (PKC) is required for long term memory storage such as classical conditioning. Stimulation of parallel fibers(PF) and climbing fibers (CF) of the cerebellum leads to production of thesecond messengers diacylglycerol, arachidonic acid, and calcium which are activators of PKC. A model is developed that describes the cascade of biochemical reactions in response to PF and CF stimulation and leading to PKC activation. Model simulations are used to evaluate the temporal specificity of PKC activation and the sensitivity of PKC activation to the interstimulusinterval (ISI) of classical conditioning. Simulations at different ISI show that if PF stimulation precedes CF stimulation, PKC activation is elevated. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:57:16