Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A computational model of synaptic transmission at the calyx of Held
Autore:
Graham, BP; Wong, AYC; Forsythe, ID;
Indirizzi:
Univ Edinburgh, Div Informat, Inst Adapt & Neural Computat, Edinburgh EH1 2QL, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH12QL Midlothian, Scotland Univ Leicester, Dept Cell Physiol & Pharmacol, Ion Channel Grp, Leicester LEI 9HN, Leics, England Univ Leicester Leicester Leics England LEI 9HN er LEI 9HN, Leics, England
Titolo Testata:
NEUROCOMPUTING
, volume: 38, anno: 2001,
pagine: 37 - 42
SICI:
0925-2312(200106)38:<37:ACMOST>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE RECEPTORS; FACILITATION; DEPRESSION; NEURONS; NUCLEUS; POOL;
Keywords:
calyx of Held; synaptic transmission; synaptic depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Graham, BP Univ Stirling, Dept Math & Comp Sci, Stirling FK9 4LA, ScotlandUniv Stirling Stirling Scotland FK9 4LA ing FK9 4LA, Scotland
Citazione:
B.P. Graham et al., "A computational model of synaptic transmission at the calyx of Held", NEUROCOMPUT, 38, 2001, pp. 37-42

Abstract

The calyx of Held is a giant glutamatergic synapse in the mammalian auditory pathway designed to ensure faithful transmission of high frequency action potential trains. Pre- and postsynaptic recordings from this synapse reveal several forms of facilitation and depression. A computational model of synaptic transmission has been developed to investigate the mechanisms underlying modulation at the calyx of Held. The model includes paired-pulse facilitation and depression due to vesicle depletion and postsynaptic AMPA receptor desensitization. Accurately matching the experimental time course and magnitude of the depression requires both slow and fast replenishment of vesicles at the presynaptic release sites. The model demonstrates that the temporal accuracy of postsynaptic spike generation depends on the amplitude of the EPSC and so accuracy decreases as the EPSCs depress. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:01:53