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Titolo:
Human labour is associated with nuclear factor-kappa B activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'
Autore:
Allport, VC; Pieber, D; Slater, DM; Newton, R; White, JO; Bennett, PR;
Indirizzi:
Queen Charlottes & Chelsea Hosp, Imperial Coll, Sch Med, Inst Obstet & Gynaecol, London W6 0XG, England Queen Charlottes & Chelsea Hosp London England W6 0XG on W6 0XG, England Natl Heart & Lung Inst, Imperial Coll, Sch Med, London SW3 6LY, England Natl Heart & Lung Inst London England SW3 6LY d, London SW3 6LY, England
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 6, volume: 7, anno: 2001,
pagine: 581 - 586
SICI:
1360-9947(200106)7:6<581:HLIAWN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN FETAL MEMBRANES; NECROSIS-FACTOR-ALPHA; DEPENDENT TRANSCRIPTION; CYCLOOXYGENASE TYPE-1; GENE-EXPRESSION; CELLS; ACTIVATION; INTERLEUKIN-1-BETA; PARTURITION; INITIATION;
Keywords:
COX-2; labour; NF-kappa B; parturition; progesterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Allport, VC Queen Charlottes & Chelsea Hosp, Imperial Coll, Sch Med, Inst Obstet & Gynaecol, Goldhawk Rd, London W6 0XG, England Queen Charlottes & Chelsea Hosp Goldhawk Rd London England W6 0XG
Citazione:
V.C. Allport et al., "Human labour is associated with nuclear factor-kappa B activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'", MOL HUM REP, 7(6), 2001, pp. 581-586

Abstract

Human labour is associated with the up-regulation of prostaglandins withinthe uterus, synthesized via the type-2 cyclo-oxygenase enzyme (COX-2), These lead to remodelling of the fetal membranes and cervix and to stimulationof myometrial contractions. In the human, the principal source of prostaglandins is the amnion, Progesterone acts to promote myometrial quiescence, and in many species the onset of labour is preceded by withdrawal of progesterone, Humans show no systemic progesterone withdrawal, although biochemical changes within the uterus are similar to those in other species. A mutualnegative interaction between the transcription factor nuclear factor (NF)-kappaB and the progesterone receptor (PR) has been reported. Using transient transfections and assays for transcriptional activation and promoter binding, we have shown that there is constitutive activity of NF-kappaB in amnion cells at the time of labour, and that COX-2 expression depends upon NF-kappaB, In cells obtained before labour, in which NF-kappaB activity is low,increasing the concentration of PR represses NF-kappaB dependent transcription, while stimulation with IL-1 beta both increases NF-kappaB activity and represses PR activity. Our data suggest that human labour is associated with constitutive NF-kappaB activity within the amnion, which functions to increase the expression of COX-2 and appears to contribute to the 'functional progesterone withdrawal'.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:33:07