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Titolo:
Progesterone inhibition of functional leptin receptor mRNA expression in human endometrium
Autore:
Koshiba, H; Kitawaki, J; Ishihara, H; Kado, N; Kusuki, I; Tsukamoto, K; Honjo, H;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 6, volume: 7, anno: 2001,
pagine: 567 - 572
SICI:
1360-9947(200106)7:6<567:PIOFLR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENSTRUAL-CYCLE; REGULATORY PROTEINS; FEMALE MICE; ISOFORMS; CLONING; CELLS; WOMEN; PREGNANCY; PLACENTA; HORMONE;
Keywords:
endometrium; intracellular signalling; leptin receptor; oestrogen; progestin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kitawaki, J Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kamigyo Ku,465 Kajii Cho, Kyoto 6028566, Japan Kyoto Prefectural Univ Med 465 Kajii Cho Kyoto Japan 6028566
Citazione:
H. Koshiba et al., "Progesterone inhibition of functional leptin receptor mRNA expression in human endometrium", MOL HUM REP, 7(6), 2001, pp. 567-572

Abstract

Leptin is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors (OB-R), Leptin is involved in the stimulation of reproductive functions, and local expression of leptin and OB-R in the ovary, oocyte, embryo, and placenta might play a role in early development. The mRNA and protein of the long form leptin receptor (OB-R-L) but not of leptin are expressed in the human endometrium and the abundance of OB-R mRNA expression varies during the menstrual cycle with a peak in the early secretory phase. We examined the steroidal regulation of OB-R-L mRNA expression. Northern blot analyses showed that in organ-cultured proliferative endometrial specimens, oestradiol (10(-9) and 10(-8) mol/l) had no acute effect on the OB-R-L mRNA expression, whereas oestradiol plus progesterone (10(-8), 10(-7) and 10(-6) mol/l) or medroxyprogesterone acetate (10(-8) and 10(-7) mol/l) suppressed the expression by similar to 50%, This progestin-induced suppression was blocked by a concomitant addition of mifepristone. Additionally, incubation of endometrial specimens in the presence of leptin resulted in the phosphorylation of its intracellular target, STAT3 (signal transducer and activator of transcription 3), These results indicate that, in the human endometrium, progestins act via the progesterone receptors to suppress functional OB-R-L mRNA expression, and may thereby alter the sensitivity of the endometrium to leptin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:15:03