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Titolo:
Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: Implications for tumor biology and treatment
Autore:
Cochran, AJ; Morton, DL; Stern, S; Lana, AMA; Essner, R; Wen, DR;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Jonsson Comprehens Canc Ctr, Los Angeles,CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles,CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Surg, Los Angeles, CA 90095 USA UnivCalif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Fed Minas Gerais, Fac Med, Dept Anat Pathol, Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil elo Horizonte, MG, Brazil St Johns Hosp & Hlth Ctr, John Wayne Canc Ctr, Santa Monica, CA USA St Johns Hosp & Hlth Ctr Santa Monica CA USA c Ctr, Santa Monica, CA USA
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 6, volume: 14, anno: 2001,
pagine: 604 - 608
SICI:
0893-3952(200106)14:6<604:SLNSPD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; IMMUNOCOMPETENCE; GANGLIOSIDES; GENERATION;
Keywords:
dendritic leukocytes; melanoma; paracortex; sentinel lymph nodes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Cochran, AJ Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 CA 90095 USA
Citazione:
A.J. Cochran et al., "Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: Implications for tumor biology and treatment", MOD PATHOL, 14(6), 2001, pp. 604-608

Abstract

The sentinel lymph node (SN) is the first node on the direct lymphatic drainage pathway from a tumor. Melanoma-associated SNs are the most likely site of early metastases and their immune functions are strikingly down-modulated. We evaluated histologic and cytologic characteristics of 21 SNs and 21nonsentinel nodes (NSNs) from melanoma patients who had clinically localized (ATCC Stage I-II) primary cutaneous melanoma. SNs showed highly significant reductions in total paracortical area and in the area of the paracortical subsector occupied by dendritic cells. The frequency of paracortical. interdigitating dendritic cells (IDCs) was dramatically reduced in SNs, and most IDCs (similar to 99%) lacked the complex dendrites associated with active antigen presentation. The release of immunosuppressive factors from the primary melanoma may induce a localized and specific paralysis in the SN, which prevents the recognition of otherwise immunogenic melanoma antigens byIDCs. This immune paralysis may facilitate the implantation and growth of melanoma cells in the SN. Cytokine therapy may be able to reverse this immune paralysis. These findings have an important practical application in thehistopathologic confirmation that a node is truly sentinel. They also offer an hypothesis to explain the failure of the immune surveillance mechanisms to identify and respond to a small primary melanoma that expresses immunogenic tumor antigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:57:40