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Titolo:
Effects of prostaglandin E-1 on the efficacy of xenogeneic extracorporeal pig liver perfusion in a canine model of acute liver failure
Autore:
Takeyama, O; Ikai, I; Yagi, T; Satoh, S; Kanazawa, A; Uesugi, T; Nishitai, R; Okabe, H; Katsura, N; Terajima, H; Yamaoka, Y;
Indirizzi:
Kyoto Univ, Dept Surg Gastroenterol, Grad Sch Med, Kyoto, Japan Kyoto Univ Kyoto Japan t Surg Gastroenterol, Grad Sch Med, Kyoto, Japan
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 6, volume: 7, anno: 2001,
pagine: 526 - 532
SICI:
1527-6465(200106)7:6<526:EOPEOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT HEPATIC-FAILURE; HYPERACUTE REJECTION; TRANSPLANTATION; ISCHEMIA; INJURY; SERUM; CELLS; ACID; MECHANISMS; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Takeyama, O Kyoto Univ Hosp, Dept Surg Gastroenterol, Sakyo Ku, 54 Kawahara Cho, Kyoto6068507, Japan Kyoto Univ Hosp 54 Kawahara Cho Kyoto Japan 6068507 07, Japan
Citazione:
O. Takeyama et al., "Effects of prostaglandin E-1 on the efficacy of xenogeneic extracorporeal pig liver perfusion in a canine model of acute liver failure", LIVER TRANS, 7(6), 2001, pp. 526-532

Abstract

Xenogeneic extracorporeal liver perfusion (ECLP) has the potential to become an important tool in the management of patients with severe liver failure. We previously showed that xenogeneic pig liver perfusion may be prolonged for up to 9 hours by the administration of prostaglandin E-1 (PGE(1)). Inthis study, we used a canine model of acute liver failure to evaluate the effects of PGE(1) on the efficacy of ECLP as a liver-assist device. Liver failure was surgically induced in 12 beagle dogs, with a control group (group 1, n = 4) not connected to the ECLP circuit. Direct cross-circulation between the dogs and the ECLP circuit using a pig liver was performed without (group 2, n = 4) or with (group 3, n = 4) continuous administration of PGE(1) through the portal vein of the pig liver. The duration of cross-circulation in group 3 (9.4 +/- 1.2 hours) was significantly longer than in group 2(4.3 +/- 1.0 hours). In addition, elevation of blood ammonia, total bile acid, and hyaluronic acid levels was less marked in group 3 compared with the other 2 groups. The ratio of branched-chain amino acids to aromatic aminoacids was also improved in group 3. The mean survival time in group 3 (26.6 +/- 0.4 hours) was significantly longer than in group 1 (15.5 +/- 1.3 hours) or group 2 (17.1 +/- 2.9 hours). Continuous administration of PGE(1) toxenogeneic ECLP resulted in a significant improvement in both liver function and survival time of dogs with surgically induced liver failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:21:38