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Titolo:
mTOR inhibitors: An overview
Autore:
Neuhaus, P; Klupp, J; Langrehr, JM;
Indirizzi:
Humboldt Univ, Charite Virchow, Dept Surg, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 Dept Surg, D-13353 Berlin, Germany
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 6, volume: 7, anno: 2001,
pagine: 473 - 484
SICI:
1527-6465(200106)7:6<473:MIAO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-TRANSPLANT RECIPIENTS; IMMUNOSUPPRESSANT SDZ-RAD; P70 S6 KINASE; ADMINISTERED SIROLIMUS RAPAMYCIN; OBLITERATIVE AIRWAY DISEASE; SMALL-BOWEL TRANSPLANTATION; HEART ALLOGRAFT-REJECTION; GRAFT VASCULAR-DISEASE; GROWTH-FACTOR ACTION; T-CELL APOPTOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Neuhaus, P Humboldt Univ, Charite Virchow, Dept Surg, Augustenburger Pl 1,D-13353 Berlin, Germany Humboldt Univ Augustenburger Pl 1 Berlin Germany D-13353 rmany
Citazione:
P. Neuhaus et al., "mTOR inhibitors: An overview", LIVER TRANS, 7(6), 2001, pp. 473-484

Abstract

Inhibitors of the mammalian target of rapamycin are a new class of immunosuppressants. In contrast to other macrolides, such as tacrolimus and cyclosporine A, they do not inhibit calcineurin and thus signal I of T-cell activation. By inhibiting signal III, the mechanism of action and side effects of sirolimus (rapamycin) and its derivative RAD are distinct from other immunosuppressants. Reports of synergism with cyclosporine A and tacrolimus in preclinical and clinical studies, avoidance of nephrotoxicity, and possibletreatment or prevention of chronic allograft rejection are leading to highexpectations for this new class of immunosuppressants. Furthermore, studies evaluating tolerance induction are being conducted. This review summarizes preclinical and clinical results published to date and exploits the future value of sirolimus and RAD for clinical transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:03:52