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Titolo:
AUTORADIOGRAPHIC COMPARISON OF [I-125] EPIDEPRIDE AND [I-125] NCQ-298BINDING TO HUMAN BRAIN EXTRASTRIATED DOPAMINE-RECEPTORS
Autore:
HALL H; HALLDIN C; JERNING E; OSTERLUND M; FARDE L; SEDVALL G;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT CLIN NEUROSCI,PSYCHIAT SECT S-17176 STOCKHOLM SWEDEN ASTRA RES CTR AB,DEPT MOL PHARMACOL S-15185 SODERTALJE SWEDEN
Titolo Testata:
Nuclear medicine and biology
fascicolo: 5, volume: 24, anno: 1997,
pagine: 389 - 393
SICI:
0969-8051(1997)24:5<389:ACO[EA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIAL ANTIPSYCHOTIC AGENTS; ANTIDOPAMINERGIC PROPERTIES; I-125 EPIDEPRIDE; INVITRO BINDING; H-3 RACLOPRIDE; D2 RECEPTORS; RADIOLIGAND; LIGAND; PET; VISUALIZATION;
Keywords:
AUTORADIOGRAPHY; D-2-DOPAMINE RECEPTORS; EPIDEPRIDE; EXTRASTRIATAL RECEPTORS; HUMAN BRAIN; NCQ 298;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Hall et al., "AUTORADIOGRAPHIC COMPARISON OF [I-125] EPIDEPRIDE AND [I-125] NCQ-298BINDING TO HUMAN BRAIN EXTRASTRIATED DOPAMINE-RECEPTORS", Nuclear medicine and biology, 24(5), 1997, pp. 389-393

Abstract

Extrastriatal D-2-dopamine receptors can be visualised in the monkey and human brain using the benzamides [C-11] and [Br-76]FLB 457 in PET and [I-123]epidepride in SPECT but not with the salicylamide analogues[Br-76]FLB 463 and [I-123]NCQ 298. To clarify the background for the differences in binding seen in vivo, we have compared the in vitro binding of [I-125]epidepride and [I-125]NCR 298, using human whole hemisphere autoradiography. The images obtained with any radioligand showed detailed distribution with very dense binding in the putamen and the caudate nucleus and with the same detailed extrastriatal distribution. Thus, the divergent results obtained in vivo cannot be explained by different binding properties of the extrastriatal receptors. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:10:47