Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Contrast Media in Abdominal Computed tomography: Optimization of delivery methods
Autore:
Han, JK; Choi, BI; Kim, AY; Kim, SJ;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Radiol, Seoul 151, South Korea Seoul Natl Univ Seoul South Korea 151 ept Radiol, Seoul 151, South Korea Seoul Natl Univ, Coll Med, Inst Radiat Med, Seoul 151, South Korea Seoul Natl Univ Seoul South Korea 151 Radiat Med, Seoul 151, South Korea
Titolo Testata:
KOREAN JOURNAL OF RADIOLOGY
fascicolo: 1, volume: 2, anno: 2001,
pagine: 28 - 36
SICI:
1229-6929(200101/03)2:1<28:CMIACT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMIC HEPATIC CT; INJECTION PROTOCOL; HELICAL CT; ENHANCEMENT; PREDICTION; VOLUME; MODEL; LIVER; RATES;
Keywords:
abdomen, CT; computed tomography (CT), contrast media; computed tomography (CT), contrast enhancement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, BI Seoul Natl Univ Hosp, Dept Radiol, Chongno Gu, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ Hosp 28 Yongon Dong Seoul South Korea 110744 rea
Citazione:
J.K. Han et al., "Contrast Media in Abdominal Computed tomography: Optimization of delivery methods", KOREAN J RA, 2(1), 2001, pp. 28-36

Abstract

Objective: To provide a systematic overview of the effects of various parameters on contrast enhancement within the same population, an animal experiment as well as a computer-aided simulation study was performed. Materials and Methods: In an animal experiment, single-level dynamic CT through the liver was performed at 5-second intervals just after the injection of contrast medium for 3 minutes. Combinations of three different amounts(1, 2, 3 mL/kg), concentrations (150, 200, 300 mgl/mL), and injection rates (0.5, 1, 2 mL/sec) were used. The CT number of the aorta (A), portal vein(P) and liver (L) was measured in each image, and time-attenuation curves for A, P and L were thus obtained. The degree of maximum enhancement (Imax)and time to reach peak enhancement (Tmax) of A, P and L were determined, and times to equilibrium (Teq) were analyzed. In the computed-aided simulation model, a program based on the amount, flow, and diffusion coefficient ofbody fluid in various compartments of the human body was designed. The input variables were the concentrations, volumes and injection rates of the contrast media used, The program generated the time-attenuation curves of A, P and L, as well as liver-to-hepatocellular carcinoma (HCC) contrast curves. On each curve, we calculated and plotted the optimal temporal window (time period above the lower threshold, which in this experiment was 10 Hounsfield units), the total area under the curve above the lower threshold, and the area within the optimal range. Results: A. Animal Experiment: At a given concentration and injection rate, an increased volume of contrast medium led to increases in Imax A, P and L. In addition, Tmax A, P, L and Teq were prolonged in parallel with increases in injection time The time-attenuation curve shifted upward and to the right, For a given volume and injection rate, an increased concentration ofcontrast medium increased the degree of aortic, portal and hepatic enhancement, though Tmax A, P and L remained the same. The time-attenuation curve shifted upward. For a given volume and concentration of contrast medium, changes in the injection rate had a prominent effect on aortic enhancement, and that of the portal vein and hepatic,parenchyma also showed some increase, though the effect was less prominent. A increased in the rate of contrastinjection led to shifting of the time enhancement curve to the left and upward. B. Computer Simulation: At a faster injection rate, there was minimalchange In the degree of hepatic attenuation, though the duration of the optimal temporal window decreased. The area between 10 and 30 HU was greatestwhen contrast media was delivered at a rate of 2-3 mL/sec. Although the total area under the curve increased in proportion to the injection rate, most of this inc-cease was above the upper threshould and thus the temporal window was narrow and the optimal area decreased. Conclusion: Increases in volume, concentration and injection rate all resulted in improved arterial enhancement. If cost was disregarded, increasing the injection volume was the most reliable way of obtaining good quality enhancement. The optimal way of delivering a given amount of contrast medium can be calculated using a computer-based mathematical model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:07:08