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Titolo:
Evaluation by contrast-enhanced MR imaging of the lateral border zone in reperfused myocardial infarction in a cat model
Autore:
Jeong, AK; Choi, SI; Kim, DH; Park, SB; Lee, SS; Choi, SH; Lim, TH;
Indirizzi:
Univ Ulsan, Coll Med, Dept Diagnost Radiol, Asan Med Ctr,Songpa Gu, Seoul 138746, South Korea Univ Ulsan Seoul South Korea 138746 Songpa Gu, Seoul 138746, South Korea
Titolo Testata:
KOREAN JOURNAL OF RADIOLOGY
fascicolo: 1, volume: 2, anno: 2001,
pagine: 21 - 27
SICI:
1229-6929(200101/03)2:1<21:EBCMIO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GD-DTPA; BLOOD-FLOW; AGENT; SIZE; DOGS; COMPLEX; TISSUE;
Keywords:
magenit resonance (MR), contrast agent; heart, MR; myocardium, infarction, gadolinium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lim, TH Univ Ulsan, Coll Med, Dept Diagnost Radiol, Asan Med Ctr,Songpa Gu, 388-1 Poongnap Dong, Seoul 138746, South Korea Univ Ulsan 388-1 Poongnap Dong Seoul South Korea 138746 uth Korea
Citazione:
A.K. Jeong et al., "Evaluation by contrast-enhanced MR imaging of the lateral border zone in reperfused myocardial infarction in a cat model", KOREAN J RA, 2(1), 2001, pp. 21-27

Abstract

Objective: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by pathological examination in a reperfused myocardial infarction cat model. Materials and Methods: In eight cats, the left anterior descending coronary artery was occluded for 90 minutes, and this was followed by 90 minutes of reperfusion. EGG-triggered breath-hold turbo spin-echo T2-weighted MR images were initially obtained along the short axis of the heart before the administration of contrast media. After the injection of Gadomer-17 and Gadophrin-2, contrast-enhanced T1-weighted M R images were obtained for th ree hours. The size of the abnormal signal area seen on each image was compared with that of the infarct area after TTC staining. To assess ultrastructuralchanges in the myocardium at the infarct area, lateral border zone and normal myocardium, electron microscopic examination was performed. Results: The high signal area seen on T2-weighted images and the enhanced area seen on Gadomer-17-enhanced T1WI were larger than the enhanced area onGadophrin-2-enhanced T1WI and the infarct area revealed by TTC staining; the difference was expressed as a percentage of the size of the total left ventricle mass (T2= 39.2 %; Gadomer-17 =37.25 % vs Gadophrin-2 = 29.6 %; TTCstaining = 28.2 %; p < 0.05). The ultrastructural changes seen at the lateral border zone were compatible with reversible myocardial damage. Conclusion: In a reperfused myocardial infarction cat model, the presence and size of the lateral border zone can be determined by means of Gadomer-17- and Gadophrin-2-enhanced MR imaging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:10:18