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Titolo:
Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a
Autore:
Bukh, J; Apgar, CL; Govindarajan, S; Emerson, SU; Purcell, RH;
Indirizzi:
NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USANIAID Bethesda MD USA 20892 , Infect Dis Lab, NIH, Bethesda, MD 20892 USA NIAID, Mol Hepatitis Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 , Infect Dis Lab, NIH, Bethesda, MD 20892 USA Univ So Calif, Rancho Los Amigos Med Ctr, Liver Res Lab, Downey, CA 90242 USA Univ So Calif Downey CA USA 90242 tr, Liver Res Lab, Downey, CA 90242 USA
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 3, volume: 8, anno: 2001,
pagine: 228 - 231
SICI:
1352-0504(200105)8:3<228:FTIRMW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE-ANALYSIS; RNA; CHIMPANZEES; PRIMATES; ANTIBODY;
Keywords:
genotype; hepatitis C virus; macaque; rhesus monkeys;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Bukh, J NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bldg 7,Room 201,7 Ctr Dr MSC 0740, Bethesda, MD 20892 USA NIAID Bldg 7,Room 201,7 Ctr Dr MSC 0740 Bethesda MD USA 20892 USA
Citazione:
J. Bukh et al., "Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a", J VIRAL HEP, 8(3), 2001, pp. 228-231

Abstract

The chimpanzee is the only recognized animal model for the study of hepatitis C virus (HCV). However, recently it was reported that rhesus monkeys were susceptible to HCV and developed hepatitis during infection. In the present study, we inoculated two rhesus monkeys each with HCV strain H77 (genotype 1a), strain HC-J6 (genotype 2a) or strain S52 (genotype 3a). Weekly serum samples were tested for liver enzyme values, HCV antibodies and HCV RNA. We did not find evidence of HCV infection in any of the monkeys during 24 weeks of follow-up. Our study demonstrates that rhesus monkeys are not readily infected with HCV and apparently do not represent a useful animal modelfor the study of HCV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:11:06