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Titolo:
Effect of hydroxyethyl starch on coagulopathy in a swine model of hemorrhagic shock resuscitation
Autore:
Via, D; Kaufmann, C; Anderson, D; Stanton, K; Rhee, P;
Indirizzi:
Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20814 Bethesda, MD 20814 USA Natl Naval Med Ctr, Dept Anesthesia, Bethesda, MD USA Natl Naval Med Ctr Bethesda MD USA tr, Dept Anesthesia, Bethesda, MD USA
Titolo Testata:
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
fascicolo: 6, volume: 50, anno: 2001,
pagine: 1076 - 1082
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASSIVE BLOOD TRANSFUSIONS; TRAUMA; COAGULATION;
Keywords:
resuscitation; hemorrhage; shock; lactated Ringer's solution; hydroxyethyl starch; albumin; coagulation; thrombelastography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Rhee, P Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA Uniformed Serv Univ Hlth Sci 4301 Jones Bridge Rd Bethesda MD USA 20814
Citazione:
D. Via et al., "Effect of hydroxyethyl starch on coagulopathy in a swine model of hemorrhagic shock resuscitation", J TRAUMA, 50(6), 2001, pp. 1076-1082

Abstract

Background: Hydroxyethyl starch (HES) has a known dose-dependant effect oncoagulopathy, The purpose of:this study was to determine the effect of HESon coagulopathy after a period of hemorrhagic shock. Methods: Anesthetized swine underwent a 15-minute, 40% blood volume hemorrhage (28 mL/kg) and a 1-hour shock period, followed by resuscitation with sham resuscitation (group I); 6% HES, 15 mL/kg (group II); 5% albumin, 15 mL/kg (group m); lactated Ringer's solution, 39 mL/kg, and 6% HES, 15 mL/kg (group TV); and lactated Ringer's solution, 39 mL/kg, and 5% albumin, 15 mL/kg (group V), Coagulation function was measured by bleeding time, prothrombin time, partial thromboplastin,time, fibrinogen, platelet count, and thromboelastography,Results: Platelet counts decreased significantly (p < 0.05) in all resuscitation groups except the sham resuscitation group. A significant decrease in platelets, fibrinogen levels, and maximum amplitude on thromboelastography was related to a dilutional effect of the fluid given and not a result ofHES at the dose tested. Conclusion: The linear dose-related coagulopathic effects of HES when given at moderate doses does not seem to be worsened by prolonged periods of hemorrhagic shock, The coagulopathy seen during resuscitation from hemorrhagic shock seems to be a dilutional effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:13:07